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γ射线对A172胶质瘤细胞的生物学效应

赵靖 李文建 高清祥 王菊芳 毛淑红 夏景光 杨建设

赵靖, 李文建, 高清祥, 王菊芳, 毛淑红, 夏景光, 杨建设. γ射线对A172胶质瘤细胞的生物学效应[J]. 原子核物理评论, 2004, 21(1): 53-55. doi: 10.11804/NuclPhysRev.21.01.053
引用本文: 赵靖, 李文建, 高清祥, 王菊芳, 毛淑红, 夏景光, 杨建设. γ射线对A172胶质瘤细胞的生物学效应[J]. 原子核物理评论, 2004, 21(1): 53-55. doi: 10.11804/NuclPhysRev.21.01.053
ZHAO Jing, LI Wen-jian, GAO Qing-xiang, WANG Ju-fang, MAO Shu-hong, XIA Jing-guang, YANG Jian-she. Biological Effectiveness in A172 Glioma Cells by γ ray Irradiation[J]. Nuclear Physics Review, 2004, 21(1): 53-55. doi: 10.11804/NuclPhysRev.21.01.053
Citation: ZHAO Jing, LI Wen-jian, GAO Qing-xiang, WANG Ju-fang, MAO Shu-hong, XIA Jing-guang, YANG Jian-she. Biological Effectiveness in A172 Glioma Cells by γ ray Irradiation[J]. Nuclear Physics Review, 2004, 21(1): 53-55. doi: 10.11804/NuclPhysRev.21.01.053

γ射线对A172胶质瘤细胞的生物学效应

doi: 10.11804/NuclPhysRev.21.01.053

Biological Effectiveness in A172 Glioma Cells by γ ray Irradiation

  • 摘要: 以不同剂量照射后的细胞存活率、 微核率和微核细胞率作为生物学终点, 研究了γ射线对A172细胞的生物学效应. 结果表明: 细胞存活率与剂量之间满足回归方程lgY=-0.064 27X+1.833 54, 其回归系数r=-0.988 6, P<0.01. 剂量为1 Gy时微核率和微核细胞率达到最大值, 此时的微核率为(66.75±3.564)%, 微核细胞率为(53.9±0.784 9)%, 微核率和微核细胞率均随着剂量的增大先增大后减小, 并分别维持在42%和37%左右. To study the biological effectiveness in A172 glioma cells induced by γray irradiation, the survival fraction and the micronucleus frequency of A172 cells was measured. The result showed that the survival fraction was negatively correlated to the radiation dose. At 1.0 Gy, the micronucleus frequency peaked about (66.75±3.564)%, and the frequency of micronucleus cells peaked about (53.9 ±0.784 9)%. As the radiation dose increasing, the micronucleus frequency and the frequency of micronucleus cells decreased and finally kept steady about 42% and 37%, respectively.
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出版历程
  • 收稿日期:  1900-01-01
  • 修回日期:  1900-01-01
  • 刊出日期:  2004-03-20

γ射线对A172胶质瘤细胞的生物学效应

doi: 10.11804/NuclPhysRev.21.01.053

摘要: 以不同剂量照射后的细胞存活率、 微核率和微核细胞率作为生物学终点, 研究了γ射线对A172细胞的生物学效应. 结果表明: 细胞存活率与剂量之间满足回归方程lgY=-0.064 27X+1.833 54, 其回归系数r=-0.988 6, P<0.01. 剂量为1 Gy时微核率和微核细胞率达到最大值, 此时的微核率为(66.75±3.564)%, 微核细胞率为(53.9±0.784 9)%, 微核率和微核细胞率均随着剂量的增大先增大后减小, 并分别维持在42%和37%左右. To study the biological effectiveness in A172 glioma cells induced by γray irradiation, the survival fraction and the micronucleus frequency of A172 cells was measured. The result showed that the survival fraction was negatively correlated to the radiation dose. At 1.0 Gy, the micronucleus frequency peaked about (66.75±3.564)%, and the frequency of micronucleus cells peaked about (53.9 ±0.784 9)%. As the radiation dose increasing, the micronucleus frequency and the frequency of micronucleus cells decreased and finally kept steady about 42% and 37%, respectively.

English Abstract

赵靖, 李文建, 高清祥, 王菊芳, 毛淑红, 夏景光, 杨建设. γ射线对A172胶质瘤细胞的生物学效应[J]. 原子核物理评论, 2004, 21(1): 53-55. doi: 10.11804/NuclPhysRev.21.01.053
引用本文: 赵靖, 李文建, 高清祥, 王菊芳, 毛淑红, 夏景光, 杨建设. γ射线对A172胶质瘤细胞的生物学效应[J]. 原子核物理评论, 2004, 21(1): 53-55. doi: 10.11804/NuclPhysRev.21.01.053
ZHAO Jing, LI Wen-jian, GAO Qing-xiang, WANG Ju-fang, MAO Shu-hong, XIA Jing-guang, YANG Jian-she. Biological Effectiveness in A172 Glioma Cells by γ ray Irradiation[J]. Nuclear Physics Review, 2004, 21(1): 53-55. doi: 10.11804/NuclPhysRev.21.01.053
Citation: ZHAO Jing, LI Wen-jian, GAO Qing-xiang, WANG Ju-fang, MAO Shu-hong, XIA Jing-guang, YANG Jian-she. Biological Effectiveness in A172 Glioma Cells by γ ray Irradiation[J]. Nuclear Physics Review, 2004, 21(1): 53-55. doi: 10.11804/NuclPhysRev.21.01.053

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