Oxygen Effect in 12C6+ Irradiation of BGC823 Cells
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摘要: 氧效应; 碳离子; 人胃癌细胞系BGC823 ;兰州重离子加速器
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关键词:
- 以体外培养的人类胃癌细胞系BGC823为材料 /
- 用兰州重离子加速器提供的能量为20MeV/u的^12C^6+离子 /
- 分别在富氧(95%O2+5%CO2)和自然条件下辐照细胞 /
- 测得这种离子的氧增比近似为1 /
- 说明在中等能量区^12C^6+离子有很低的氧效应。GastrictumourBGC823cellsculturedinnaturalandrichoxygenic(95%O2+5%CO2)environmentareirradiatedwithenergyof20MeV/u^12C^6+ionsatHIRFL.AverageOER≈1isdeducedfromsurvivalcurvesforcellsinnaturalandrichoxygenicenvironment.ThisrelativelylowOERvalueindicatesthatmediumenergycarbonionsaresuitableforthecanceroustherapy.
Abstract: Gastric tumour BGC823 cells cultured in natural and rich oxygenic(95 %O2+5% CO2 )environment are irradiated with energy of 20 MeV/u ^12C^6+ ions at HIRFL. Average OER≈1 is deduced from survival curves for cells in natural and rich oxygenic environment. This relatively low OER value indicates that medium energy carbon ions are suitable for the cancerous therapy.-
Key words:
- oxygen effect /
- 12C6+ ions /
- BGC823 /
- HIRFL /
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