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利用超分次技术进行肿瘤治疗的探讨

金晓东 李强 郭传玲 郝冀芳 王菊芳 李文建 闫铮 戴中颖

金晓东, 李强, 郭传玲, 郝冀芳, 王菊芳, 李文建, 闫铮, 戴中颖. 利用超分次技术进行肿瘤治疗的探讨[J]. 原子核物理评论, 2006, 23(2): 242-245. doi: 10.11804/NuclPhysRev.23.02.242
引用本文: 金晓东, 李强, 郭传玲, 郝冀芳, 王菊芳, 李文建, 闫铮, 戴中颖. 利用超分次技术进行肿瘤治疗的探讨[J]. 原子核物理评论, 2006, 23(2): 242-245. doi: 10.11804/NuclPhysRev.23.02.242
JIN Xiao-dong, LI Qiang, GUO Chuan-ling, WANG Ju-fang, LI Wen-jian, YAN Zheng, DAI Zhong-ying, . Theoretical Exploration on Ultra-fractionated Radiotherapy[J]. Nuclear Physics Review, 2006, 23(2): 242-245. doi: 10.11804/NuclPhysRev.23.02.242
Citation: JIN Xiao-dong, LI Qiang, GUO Chuan-ling, WANG Ju-fang, LI Wen-jian, YAN Zheng, DAI Zhong-ying, . Theoretical Exploration on Ultra-fractionated Radiotherapy[J]. Nuclear Physics Review, 2006, 23(2): 242-245. doi: 10.11804/NuclPhysRev.23.02.242

利用超分次技术进行肿瘤治疗的探讨

doi: 10.11804/NuclPhysRev.23.02.242

Theoretical Exploration on Ultra-fractionated Radiotherapy

  • 摘要: 以人类肝癌细胞SMMC-7721和正常肝细胞L02为研究对象,以这两种细胞0.3Gy时超敏感性的存活数据为基础,从理论上探讨了γ射线照射时,用超分次技术治疗肝癌的可能性。经过计算发现:如果目标肿瘤和周围的正常组织超敏感性的存活差异提高到3%,即可利用超分次技术对肿瘤进行治疗。应用超分次进行分次照射时,照射的结果与分次的间隔时间有关。对这一现象的机理进行了一定的探讨,发现时间间隔与细胞G2期的长短可能存在一定的相关性。Based on the survival data of human hepatoma SMMC-7721 and normal liver L02 cells irradiated with γ-rays at 0.3 Gy and 2 Gy, the possibility of uhra-fractionated radiotherapy is discussed in this paper. According to calculations, it is found that if the difference in cell survival between target tumor and adjacent normal tissue is up to 3%, radiotherapy using HRS would be realized through uhra-fractionation. Furthermore, the low-dose response is time-dependent. After analyzing this phenomenon, it was pointed that there would be a correlation between fractionation interval and the duration of cell G2 phase.
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  • 收稿日期:  1900-01-01
  • 修回日期:  1900-01-01
  • 刊出日期:  2006-06-20

利用超分次技术进行肿瘤治疗的探讨

doi: 10.11804/NuclPhysRev.23.02.242

摘要: 以人类肝癌细胞SMMC-7721和正常肝细胞L02为研究对象,以这两种细胞0.3Gy时超敏感性的存活数据为基础,从理论上探讨了γ射线照射时,用超分次技术治疗肝癌的可能性。经过计算发现:如果目标肿瘤和周围的正常组织超敏感性的存活差异提高到3%,即可利用超分次技术对肿瘤进行治疗。应用超分次进行分次照射时,照射的结果与分次的间隔时间有关。对这一现象的机理进行了一定的探讨,发现时间间隔与细胞G2期的长短可能存在一定的相关性。Based on the survival data of human hepatoma SMMC-7721 and normal liver L02 cells irradiated with γ-rays at 0.3 Gy and 2 Gy, the possibility of uhra-fractionated radiotherapy is discussed in this paper. According to calculations, it is found that if the difference in cell survival between target tumor and adjacent normal tissue is up to 3%, radiotherapy using HRS would be realized through uhra-fractionation. Furthermore, the low-dose response is time-dependent. After analyzing this phenomenon, it was pointed that there would be a correlation between fractionation interval and the duration of cell G2 phase.

English Abstract

金晓东, 李强, 郭传玲, 郝冀芳, 王菊芳, 李文建, 闫铮, 戴中颖. 利用超分次技术进行肿瘤治疗的探讨[J]. 原子核物理评论, 2006, 23(2): 242-245. doi: 10.11804/NuclPhysRev.23.02.242
引用本文: 金晓东, 李强, 郭传玲, 郝冀芳, 王菊芳, 李文建, 闫铮, 戴中颖. 利用超分次技术进行肿瘤治疗的探讨[J]. 原子核物理评论, 2006, 23(2): 242-245. doi: 10.11804/NuclPhysRev.23.02.242
JIN Xiao-dong, LI Qiang, GUO Chuan-ling, WANG Ju-fang, LI Wen-jian, YAN Zheng, DAI Zhong-ying, . Theoretical Exploration on Ultra-fractionated Radiotherapy[J]. Nuclear Physics Review, 2006, 23(2): 242-245. doi: 10.11804/NuclPhysRev.23.02.242
Citation: JIN Xiao-dong, LI Qiang, GUO Chuan-ling, WANG Ju-fang, LI Wen-jian, YAN Zheng, DAI Zhong-ying, . Theoretical Exploration on Ultra-fractionated Radiotherapy[J]. Nuclear Physics Review, 2006, 23(2): 242-245. doi: 10.11804/NuclPhysRev.23.02.242

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