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姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究

赵邱越 王振华 谢漪 许帅 狄翠霞 张红

赵邱越, 王振华, 谢漪, 许帅, 狄翠霞, 张红. 姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究[J]. 原子核物理评论, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
引用本文: 赵邱越, 王振华, 谢漪, 许帅, 狄翠霞, 张红. 姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究[J]. 原子核物理评论, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
ZHAO Qiuyue, WANG Zhenhua, XIE Yi, XU Shuai, DI Cuixia, ZHANG Hong. Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
Citation: ZHAO Qiuyue, WANG Zhenhua, XIE Yi, XU Shuai, DI Cuixia, ZHANG Hong. Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101

姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究

doi: 10.11804/NuclPhysRev.31.01.101

Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams

  • 摘要: 探讨姜黄素(Curcumin,简称Cur) 对重离子辐射损伤小鼠睾丸组织的防护作用。小鼠灌胃不同剂量的Cur 后给予4 Gy 剂量12C6+离子束全身单次照射。24 h 后对小鼠睾丸组织形态学变化进行观察,并测定丙二醛(MDA) 含量、超氧化物歧化酶(SOD) 活性和过氧化氢酶(CAT) 活性。结果显示:中、高浓度Cur 预处理组对小鼠睾丸组织的形态具有较好的保护作用;低、中浓度Cur 预处理组MDA 含量显著降低(P < 0:05);与单纯照射组相比,低浓度Cur 预处理组SOD 活性水平和中浓度Cur 预处理组CAT 活性水平显著提高(P < 0:05)。结果表明:Cur 对重离子全身辐射小鼠的抗氧化系统有一定的激活效应,对辐射损伤有一定的防护作用,其机制可能与Cur 清除自由基,保护脂质和蛋白质有关。The protective effect of Curcumin (Cur) against the irradiation damage of testis in mice induced by 12C6+ ion beams was studied. Male Kung-Ming mice were exposed to whole body uniformly irradiated with 12C6+ ion beams at 4 Gy after pretreated with Cur of different concentration. Then histological alterations were observed. Moreover, malonaldehyde (MDA) level, superoxide dismutase (SOD) activity and catalase (CAT) activity were also measured at 24 h after irradiation. The result showed that middle and high dose Cur pretreated have a good protective effect. Compared with irradiated group, MDA level decreased dramatically in the group of pretreatment with low and middle dose Cur (P < 0:05). On the contrary, SOD activity in the pretreated group with low dose Cur significantly increased (P <0:05). Similarly, CAT activity in the pretreated group with middle dose Cur significantly increased (P <0:05). Data suggested that Cur could activate antioxidant system of testis in mice induced by12C6+ ion beams, it have some protective effect to radiation damage. The mechanism may involve in its scavenging reactive oxidant species and thenprotecting lipid and protein capability.
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  • 收稿日期:  1900-01-01
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  • 刊出日期:  2014-03-20

姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究

doi: 10.11804/NuclPhysRev.31.01.101

摘要: 探讨姜黄素(Curcumin,简称Cur) 对重离子辐射损伤小鼠睾丸组织的防护作用。小鼠灌胃不同剂量的Cur 后给予4 Gy 剂量12C6+离子束全身单次照射。24 h 后对小鼠睾丸组织形态学变化进行观察,并测定丙二醛(MDA) 含量、超氧化物歧化酶(SOD) 活性和过氧化氢酶(CAT) 活性。结果显示:中、高浓度Cur 预处理组对小鼠睾丸组织的形态具有较好的保护作用;低、中浓度Cur 预处理组MDA 含量显著降低(P < 0:05);与单纯照射组相比,低浓度Cur 预处理组SOD 活性水平和中浓度Cur 预处理组CAT 活性水平显著提高(P < 0:05)。结果表明:Cur 对重离子全身辐射小鼠的抗氧化系统有一定的激活效应,对辐射损伤有一定的防护作用,其机制可能与Cur 清除自由基,保护脂质和蛋白质有关。The protective effect of Curcumin (Cur) against the irradiation damage of testis in mice induced by 12C6+ ion beams was studied. Male Kung-Ming mice were exposed to whole body uniformly irradiated with 12C6+ ion beams at 4 Gy after pretreated with Cur of different concentration. Then histological alterations were observed. Moreover, malonaldehyde (MDA) level, superoxide dismutase (SOD) activity and catalase (CAT) activity were also measured at 24 h after irradiation. The result showed that middle and high dose Cur pretreated have a good protective effect. Compared with irradiated group, MDA level decreased dramatically in the group of pretreatment with low and middle dose Cur (P < 0:05). On the contrary, SOD activity in the pretreated group with low dose Cur significantly increased (P <0:05). Similarly, CAT activity in the pretreated group with middle dose Cur significantly increased (P <0:05). Data suggested that Cur could activate antioxidant system of testis in mice induced by12C6+ ion beams, it have some protective effect to radiation damage. The mechanism may involve in its scavenging reactive oxidant species and thenprotecting lipid and protein capability.

English Abstract

赵邱越, 王振华, 谢漪, 许帅, 狄翠霞, 张红. 姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究[J]. 原子核物理评论, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
引用本文: 赵邱越, 王振华, 谢漪, 许帅, 狄翠霞, 张红. 姜黄素对重离子辐射损伤小鼠睾丸组织的防护作用研究[J]. 原子核物理评论, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
ZHAO Qiuyue, WANG Zhenhua, XIE Yi, XU Shuai, DI Cuixia, ZHANG Hong. Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
Citation: ZHAO Qiuyue, WANG Zhenhua, XIE Yi, XU Shuai, DI Cuixia, ZHANG Hong. Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101

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