碳离子治疗中分野照射技术的Monte Carlo模拟

黄齐艳; 刘新国; 戴中颖; 贺鹏博; 申国盛; 马圆圆; 闫渊林; 付廷岩; 李强

doi:10.11804/NuclPhysRev.32.01.115

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碳离子治疗中分野照射技术的Monte Carlo模拟

黄齐艳, 刘新国, 戴中颖, 贺鹏博, 申国盛, 马圆圆, 闫渊林, 付廷岩, 李强

文章导航 > 原子核物理评论 > 2015 > 32(1): 115-120

黄齐艳, 刘新国, 戴中颖, 贺鹏博, 申国盛, 马圆圆, 闫渊林, 付廷岩, 李强. 碳离子治疗中分野照射技术的Monte Carlo模拟[J]. 原子核物理评论, 2015, 32(1): 115-120. doi: 10.11804/NuclPhysRev.32.01.115

引用本文:

HUANG Qiyan, LIU Xinguo, DAI Zhongying, HE Pengbo, SHEN Guosheng, MA Yuanyuan, YAN Yuanlin, FU Tingyan, LI Qiang. Monte Carlo Simulation of Field Patching Technique in Carbon Ion Beam Therapy[J]. Nuclear Physics Review, 2015, 32(1): 115-120. doi: 10.11804/NuclPhysRev.32.01.115

Citation:

HUANG Qiyan, LIU Xinguo, DAI Zhongying, HE Pengbo, SHEN Guosheng, MA Yuanyuan, YAN Yuanlin, FU Tingyan, LI Qiang. Monte Carlo Simulation of Field Patching Technique in Carbon Ion Beam Therapy[J]. Nuclear Physics Review, 2015, 32(1): 115-120. doi: 10.11804/NuclPhysRev.32.01.115

碳离子治疗中分野照射技术的Monte Carlo模拟

doi: 10.11804/NuclPhysRev.32.01.115

中国科学院近代物理研究所,兰州 730000;
中国科学院重离子束辐射生物医学重点实验室,兰州 730000;
中国科学院大学,北京 100049

Monte Carlo Simulation of Field Patching Technique in Carbon Ion Beam Therapy

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

摘要: 为阐述分野照射治疗方式应用于中国科学院近代物理研究所(IMP) 肿瘤重离子临床治疗试验研究的理论基础，利用Monte Carlo (MC) 软件包Gate/Geant4 模拟计算了碳离子束分野照射分衔接处的横向剂量分布，得到了患者摆位误差±1.0 mm范围内的横向剂量分布和分野衔接处中心剂量随分野间距的变化关系，计算了分野间距5.0 mm的横向剂量分布。将分野间距5.0 mm的分野照射与整野照射的MC结果进行比较，发现：在靶区范围内两者模拟的剂量偏差在6.8% 以内，符合程度较好，并提出了在患者定位精确度较高的情况下(即患者治疗体位摆位误差在±1.0 mm范围) 解决分野衔接处剂量热点问题的可行方法，从而较大幅度地提高了分野照射时靶区范围内的剂量均匀性。To characterize the theoretical basis of eld patching technique in carbon ion beam therapy, Monte Carlo software package Gate/Geant4 was used to simulate the lateral dose distribution of matched elds. The lateral dose distribution of the matched elds within 1.0 millimeter of patient positioning error and the relationship between the central dose of the matched elds and the eld patching gap were obtained. Moreover, the lateral dose pro le of eld patching irradiation with 5.0 mm gap was simulated. While comparing the lateral dose distribution of eld patching irradiation with 5.0 mm gap with the undivided eld irradiation, a good agreement between both results with a maximum dose deviation of 6.8% was observed within the target volume.Hence a feasible method for solving the issue of dose hotspots during eld patching under the condition of higher patient positioning accuracies (patient positioning error within 1.0 millimeter) was proposed and the dose homogeneit within the target volume could be greatly improved when eld patching technique is adopted in carbon ion beam therapy.
- 碳离子治疗 /
- 分野照射 /
- Monte Carlo /
- Gate/Geant4 /
- 横向剂量分布
Abstract: To characterize the theoretical basis of eld patching technique in carbon ion beam therapy, Monte Carlo software package Gate/Geant4 was used to simulate the lateral dose distribution of matched elds. The lateral dose distribution of the matched elds within 1.0 millimeter of patient positioning error and the relationship between the central dose of the matched elds and the eld patching gap were obtained. Moreover, the lateral dose pro le of eld patching irradiation with 5.0 mm gap was simulated. While comparing the lateral dose distribution of eld patching irradiation with 5.0 mm gap with the undivided eld irradiation, a good agreement between both results with a maximum dose deviation of 6.8% was observed within the target volume.Hence a feasible method for solving the issue of dose hotspots during eld patching under the condition of higher patient positioning accuracies (patient positioning error within 1.0 millimeter) was proposed and the dose homogeneit within the target volume could be greatly improved when eld patching technique is adopted in carbon ion beam therapy.
- carbon ion beam therapy /
- eld patching /
- Monte Carlo /
- Gate/Geant4 /
- lateral dose distribution

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碳离子治疗中分野照射技术的Monte Carlo模拟

doi: 10.11804/NuclPhysRev.32.01.115

中国科学院近代物理研究所,兰州 730000;

中国科学院重离子束辐射生物医学重点实验室,兰州 730000;

中国科学院大学,北京 100049

收稿日期: 1900-01-01
修回日期: 1900-01-01
刊出日期: 2015-03-20

关键词:

碳离子治疗 /

分野照射 /

Monte Carlo /

Gate/Geant4 /

横向剂量分布

摘要: 为阐述分野照射治疗方式应用于中国科学院近代物理研究所(IMP) 肿瘤重离子临床治疗试验研究的理论基础，利用Monte Carlo (MC) 软件包Gate/Geant4 模拟计算了碳离子束分野照射分衔接处的横向剂量分布，得到了患者摆位误差±1.0 mm范围内的横向剂量分布和分野衔接处中心剂量随分野间距的变化关系，计算了分野间距5.0 mm的横向剂量分布。将分野间距5.0 mm的分野照射与整野照射的MC结果进行比较，发现：在靶区范围内两者模拟的剂量偏差在6.8% 以内，符合程度较好，并提出了在患者定位精确度较高的情况下(即患者治疗体位摆位误差在±1.0 mm范围) 解决分野衔接处剂量热点问题的可行方法，从而较大幅度地提高了分野照射时靶区范围内的剂量均匀性。To characterize the theoretical basis of eld patching technique in carbon ion beam therapy, Monte Carlo software package Gate/Geant4 was used to simulate the lateral dose distribution of matched elds. The lateral dose distribution of the matched elds within 1.0 millimeter of patient positioning error and the relationship between the central dose of the matched elds and the eld patching gap were obtained. Moreover, the lateral dose pro le of eld patching irradiation with 5.0 mm gap was simulated. While comparing the lateral dose distribution of eld patching irradiation with 5.0 mm gap with the undivided eld irradiation, a good agreement between both results with a maximum dose deviation of 6.8% was observed within the target volume.Hence a feasible method for solving the issue of dose hotspots during eld patching under the condition of higher patient positioning accuracies (patient positioning error within 1.0 millimeter) was proposed and the dose homogeneit within the target volume could be greatly improved when eld patching technique is adopted in carbon ion beam therapy.

English Abstract

Monte Carlo Simulation of Field Patching Technique in Carbon Ion Beam Therapy

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2015-03-20

Keywords:

Abstract: To characterize the theoretical basis of eld patching technique in carbon ion beam therapy, Monte Carlo software package Gate/Geant4 was used to simulate the lateral dose distribution of matched elds. The lateral dose distribution of the matched elds within 1.0 millimeter of patient positioning error and the relationship between the central dose of the matched elds and the eld patching gap were obtained. Moreover, the lateral dose pro le of eld patching irradiation with 5.0 mm gap was simulated. While comparing the lateral dose distribution of eld patching irradiation with 5.0 mm gap with the undivided eld irradiation, a good agreement between both results with a maximum dose deviation of 6.8% was observed within the target volume.Hence a feasible method for solving the issue of dose hotspots during eld patching under the condition of higher patient positioning accuracies (patient positioning error within 1.0 millimeter) was proposed and the dose homogeneit within the target volume could be greatly improved when eld patching technique is adopted in carbon ion beam therapy.

引用本文:

Citation:

HUANG Qiyan, LIU Xinguo, DAI Zhongying, HE Pengbo, SHEN Guosheng, MA Yuanyuan, YAN Yuanlin, FU Tingyan, LI Qiang. Monte Carlo Simulation of Field Patching Technique in Carbon Ion Beam Therapy[J]. Nuclear Physics Review, 2015, 32(1): 115-120. doi: 10.11804/NuclPhysRev.32.01.115