关键词: 
酵母β-葡聚糖 /
¹²C⁶⁺离子 /
辐射防护

摘要:  用¹²C⁶⁺离子束对小鼠进行一次性全身辐照， 检测不同剂量的酵母β-葡聚糖对¹²C⁶⁺辐射损伤小鼠免疫系统的防护作用。 辐照后观察小鼠的体重、 毛色及行为变化， 照后第2天和第7天检测小鼠外周血中白细胞含量， 照后第8天检测小鼠胸腺和脾脏内SOD， GSHPX活性和MDA含量。 实验结果表明， 给予酵母β葡聚糖能减缓辐照引起的小鼠体重急剧下降， 增加小鼠外周血中白细胞含量，不同程度地恢复胸腺和脾脏SOD和GSHPX活性， 降低胸腺和脾脏MDA含量。 表明酵母β-葡聚糖对¹²C⁶⁺引起的小鼠辐射损伤具有防护作用。 To detect Yeast β-glucan’s protective effect on mice’s immune system after C ion beam radiation， mice were used as the test model. We observed the weight， hair color and behavior of mice everyday within a 7 d period of time after irradiation. Meanwhile， the content of white blood cell， on the 2nd and 7th day after irradiation was detected. We detected the thymus and spleen SOD， GSHPX activity and MDA content of the mice on the 8th day. The results showed that yeast βglucan could reduce the rapid weight loss of mice， increase white blood cell content， increase thymus and spleen SOD， GSHPX activity， decrease MDA content of thymus and spleen. These results indicate that yeast βglucan can protect mice’s immune system against C ion beam radiation damage.
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