重离子放射治疗双微小展宽峰组合照射方法

姬腾飞; 刘新国; 戴中颖; 贺鹏博; 闫渊林; 黄齐艳; 李强

doi:10.11804/NuclPhysRev.33.03.345

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重离子放射治疗双微小展宽峰组合照射方法

姬腾飞, 刘新国, 戴中颖, 贺鹏博, 闫渊林, 黄齐艳, 李强

文章导航 > 原子核物理评论 > 2016 > 33(3): 345-352

姬腾飞, 刘新国, 戴中颖, 贺鹏博, 闫渊林, 黄齐艳, 李强. 重离子放射治疗双微小展宽峰组合照射方法[J]. 原子核物理评论, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345

引用本文:

JI Tengfei, LIU Xinguo, DAI Zhongying, HE Pengbo, YAN Yuanlin, HUANG Qiyan, LI Qiang. Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy[J]. Nuclear Physics Review, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345

Citation:

JI Tengfei, LIU Xinguo, DAI Zhongying, HE Pengbo, YAN Yuanlin, HUANG Qiyan, LI Qiang. Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy[J]. Nuclear Physics Review, 2016, 33(3): 345-352. doi: 10.11804/NuclPhysRev.33.03.345

重离子放射治疗双微小展宽峰组合照射方法

doi: 10.11804/NuclPhysRev.33.03.345

姬腾飞^1,2,3,4,
刘新国^1,2,3,
戴中颖^1,2,3,
贺鹏博^1,2,3,
闫渊林^1,2,3,4,
黄齐艳^1,2,
李强^1,2,3,

1.
中国科学院近代物理研究所, 兰州 730000;
2.
中国科学院重离子束辐射生物医学重点实验室, 兰州 730000;
3.
甘肃省重离子束辐射医学应用基础重点实验室, 兰州 730000;
4.
中国科学院大学, 北京 100049

基金项目: 国家自然科学基金委员会-中国科学院大科学装置联合基金资助项目（U1232207）；国家自然科学基金资助项目（11205217，11475231，11075191）；国家科技支撑计划资助项目（2015BAI01B11）

详细信息

作者简介:
姬腾飞(1992-),男,河南商丘人,硕士研究生,从事重离子治疗技术基础研究;E-mail:jitf@impcas.ac.cn

通讯作者: 李强,E-mail:liqiang@impcas.ac.cn

中图分类号: R815.6

Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy

JI Tengfei^1,2,3,4,
LIU Xinguo^1,2,3,
DAI Zhongying^1,2,3,
HE Pengbo^1,2,3,
YAN Yuanlin^1,2,3,4,
HUANG Qiyan^1,2,
LI Qiang^{1,2,3
,}

1.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
2.
Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;
3.
Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China;
4.
University of Chinese Academy of Sciences, Beijing 100049, China

Funds: NSFC-CAS Joint Fund for Research Based on Large-scaled Scientific Facilities (U1232207); National Natural Science Foundation of China (11205217, 11475231, 11075191); National Key Technology Support Program of the Ministry of Science and Technology of China (2015BAI01B11)

摘要: 在基于被动式束流配送系统的分层适形重离子治疗当中，需要利用微型脊形过滤器（mini ridge filter，mini-RF）将单能重离子束Bragg峰展宽为峰区近似高斯分布的微小展宽峰（mini spread-out Bragg peak，mini-SOBP），从而达到减少照射分层数及照射时间的目的。采用较宽的mini-SOBP可以有效减少照射分层数，但会增大展宽Bragg峰（SOBP）远端剂量跌落距离，增加对靶区后方正常组织或危及器官的辐照剂量。这一问题可以通过双mini-SOBP的组合照射方法来解决。使用2种mini-RF对单能重离子束Bragg峰略微展宽得到2种半高宽（FWHM）且剂量分布近似高斯分布的mini-SOBP，通过基于放射生物学模型的剂量优化，证实了在SOBP平顶区按生物有效剂量均匀和物理吸收剂量均匀的展宽情况下，双mini-SOBP组合照射方法均可以在减少照射分层数的同时较大幅度地减小SOBP远端剂量跌落距离。

In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.
- 重离子治疗 /
- 剂量优化 /
- SOBP远端剂量跌落距离 /
- 微小展宽峰 /
- 组合照射
Abstract: In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.
- heavy-ion therapy /
- dose optimization /
- distal dose fall-off distance /
- mini-SOBP /
- combinatorial irradiation

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重离子放射治疗双微小展宽峰组合照射方法

doi: 10.11804/NuclPhysRev.33.03.345

1. 中国科学院近代物理研究所, 兰州 730000;

2. 中国科学院重离子束辐射生物医学重点实验室, 兰州 730000;

3. 甘肃省重离子束辐射医学应用基础重点实验室, 兰州 730000;

4. 中国科学院大学, 北京 100049

作者简介:
姬腾飞(1992-),男,河南商丘人,硕士研究生,从事重离子治疗技术基础研究;E-mail:jitf@impcas.ac.cn

通讯作者: 李强,E-mail:liqiang@impcas.ac.cn

收稿日期: 2015-09-18
修回日期: 2015-10-08
刊出日期: 2016-09-20

中图分类号: R815.6

关键词:

摘要: 在基于被动式束流配送系统的分层适形重离子治疗当中，需要利用微型脊形过滤器（mini ridge filter，mini-RF）将单能重离子束Bragg峰展宽为峰区近似高斯分布的微小展宽峰（mini spread-out Bragg peak，mini-SOBP），从而达到减少照射分层数及照射时间的目的。采用较宽的mini-SOBP可以有效减少照射分层数，但会增大展宽Bragg峰（SOBP）远端剂量跌落距离，增加对靶区后方正常组织或危及器官的辐照剂量。这一问题可以通过双mini-SOBP的组合照射方法来解决。使用2种mini-RF对单能重离子束Bragg峰略微展宽得到2种半高宽（FWHM）且剂量分布近似高斯分布的mini-SOBP，通过基于放射生物学模型的剂量优化，证实了在SOBP平顶区按生物有效剂量均匀和物理吸收剂量均匀的展宽情况下，双mini-SOBP组合照射方法均可以在减少照射分层数的同时较大幅度地减小SOBP远端剂量跌落距离。

In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.

English Abstract

Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy

1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

2. Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

3. Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China;

4. University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 2015-09-18
Rev Recd Date: 2015-10-08
Publish Date: 2016-09-20

Keywords:

Abstract: In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.

引用本文: