Advanced Search
Volume 24 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Nuclear Physics Review  > 2007  >  24(1): 72-75

WANG Yan-ling, ZHANG Hong, LI Ning, HAO Ji-fang, ZHAO Wei-ping. Effects of Cellcycle Progression of A549 Cells Induced by 12C6+ Ion Irradiation[J]. Nuclear Physics Review, 2007, 24(1): 72-75. doi: 10.11804/NuclPhysRev.24.01.072
Citation: WANG Yan-ling, ZHANG Hong, LI Ning, HAO Ji-fang, ZHAO Wei-ping. Effects of Cellcycle Progression of A549 Cells Induced by 12C6+ Ion Irradiation[J]. Nuclear Physics Review, 2007, 24(1): 72-75. doi: 10.11804/NuclPhysRev.24.01.072
shu

Effects of Cellcycle Progression of A549 Cells Induced by 12C6+ Ion Irradiation

doi: 10.11804/NuclPhysRev.24.01.072

  • 1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Graduate School of Chinese Academy of Sciences, Beijing 100049, China

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2007-03-20
  • To investigate the effects of cellcycle progression of A549 cell induced by 12C6+ ion irradiation at different doses, the survival fractions of the A549 cells were determined by colonyforming assay; cell cycles were analyzed by FACS at 12 h or 24 h after irradiation. The results showed that the percentage of survival in the A549 cells decreased with irradiation doses. Compared with control group， the percentage of the cells in G0/G1 phase significantly increased at 12 h after irradiation with different doses of 12C6+ ions. However， at 24 h after irradiation the percentage of the cells in G0/G1 phase significantly increased with 1.0 Gy 12C6+ ions， while the cells showed increasing percentage in G2/M phase with 2.0, 4.0 or 6.0 Gy 12C6+ ions. The results suggested that G1 cell cycle checkpoint was activated in 12—24 h after irradiation with 1.0 Gy 12C6+ ions， but after irradiation with 2.0—6.0 Gy 12C6+ ions， the cellcycle progression of the A549 cells changed with time.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(1902) PDF downloads(742) Cited by()

Proportional views

Effects of Cellcycle Progression of A549 Cells Induced by 12C6+ Ion Irradiation

doi: 10.11804/NuclPhysRev.24.01.072
  • 1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Graduate School of Chinese Academy of Sciences, Beijing 100049, China
  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2007-03-20

Abstract: To investigate the effects of cellcycle progression of A549 cell induced by 12C6+ ion irradiation at different doses, the survival fractions of the A549 cells were determined by colonyforming assay; cell cycles were analyzed by FACS at 12 h or 24 h after irradiation. The results showed that the percentage of survival in the A549 cells decreased with irradiation doses. Compared with control group， the percentage of the cells in G0/G1 phase significantly increased at 12 h after irradiation with different doses of 12C6+ ions. However， at 24 h after irradiation the percentage of the cells in G0/G1 phase significantly increased with 1.0 Gy 12C6+ ions， while the cells showed increasing percentage in G2/M phase with 2.0, 4.0 or 6.0 Gy 12C6+ ions. The results suggested that G1 cell cycle checkpoint was activated in 12—24 h after irradiation with 1.0 Gy 12C6+ ions， but after irradiation with 2.0—6.0 Gy 12C6+ ions， the cellcycle progression of the A549 cells changed with time.

WANG Yan-ling, ZHANG Hong, LI Ning, HAO Ji-fang, ZHAO Wei-ping. Effects of Cellcycle Progression of A549 Cells Induced by 12C6+ Ion Irradiation[J]. Nuclear Physics Review, 2007, 24(1): 72-75. doi: 10.11804/NuclPhysRev.24.01.072
Citation: WANG Yan-ling, ZHANG Hong, LI Ning, HAO Ji-fang, ZHAO Wei-ping. Effects of Cellcycle Progression of A549 Cells Induced by 12C6+ Ion Irradiation[J]. Nuclear Physics Review, 2007, 24(1): 72-75. doi: 10.11804/NuclPhysRev.24.01.072
shu

    HTML

Catalog

    Copyright by 《Nuclear Physics Review》Editorial Office

    Address: 509 Nanchang Road, LanzhouPostCode: 730000Tel: 0931-4969374, 4969371Fax: 0931-8272100E-mail:npr@impcas.ac.cn

    陇ICP备2023003351号-2 甘公网安备 62010202000723号

    Supported by: Beijing Renhe Information Technology Co. Ltd  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return