Effect of Concentration of DNA and Dose Rate in DNA Damage Induced by γ Ray

KONG Fu-quan; WANG Xiao; NI Mei-nan; SUI Li; YANG Ming-jian

doi:10.11804/NuclPhysRev.24.02.103

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Article Navigation > Nuclear Physics Review > 2007 > 24(2): 103-107

KONG Fu-quan, WANG Xiao, NI Mei-nan, SUI Li, YANG Ming-jian, . Effect of Concentration of DNA and Dose Rate in DNA Damage Induced by γ Ray[J]. Nuclear Physics Review, 2007, 24(2): 103-107. doi: 10.11804/NuclPhysRev.24.02.103

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KONG Fu-quan, WANG Xiao, NI Mei-nan, SUI Li, YANG Ming-jian, . Effect of Concentration of DNA and Dose Rate in DNA Damage Induced by γ Ray[J]. Nuclear Physics Review, 2007, 24(2): 103-107. doi: 10.11804/NuclPhysRev.24.02.103

Effect of Concentration of DNA and Dose Rate in DNA Damage Induced by γ Ray

doi: 10.11804/NuclPhysRev.24.02.103

1 China Institute of Atomic Energy, Beijing 102413, China; 2 School of Science, Hebei University of Technology, Tianjin 300130, China;3 Key Laboratory of Beam Technology and Modification of Ministry of Education, Beijing Normal University, Beijing 100875, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2007-06-20

Abstract

As two factors， the changes of concentration of DNA and dose rate are of significance in the study of DNA damage induced by irradiation. The influence of DNA damage induced by γ ray at different concentration of DNA under different dose rate was investigated. The result of gel electrophoresis indicate that DNA molecules were damaged severely as the concentration of DNA decreasing. The number of double strand breakages per DNA were obtained by the software of Alpha Innotech and theoretical analysis. It shows that the numbers of double strand breakages per DNA presented nonlinear feature as the concentration of DNA decreasing, and the dose rate had little influence on DNA damage.
- γ ray,
- DNA damage,
- concentration of DNA,
- dose rate,
- pUC19
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沈阳化工大学材料科学与工程学院沈阳 110142

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Effect of Concentration of DNA and Dose Rate in DNA Damage Induced by γ Ray

doi: 10.11804/NuclPhysRev.24.02.103

1 China Institute of Atomic Energy, Beijing 102413, China; 2 School of Science, Hebei University of Technology, Tianjin 300130, China;3 Key Laboratory of Beam Technology and Modification of Ministry of Education, Beijing Normal University, Beijing 100875, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2007-06-20

Key words:

Abstract: As two factors， the changes of concentration of DNA and dose rate are of significance in the study of DNA damage induced by irradiation. The influence of DNA damage induced by γ ray at different concentration of DNA under different dose rate was investigated. The result of gel electrophoresis indicate that DNA molecules were damaged severely as the concentration of DNA decreasing. The number of double strand breakages per DNA were obtained by the software of Alpha Innotech and theoretical analysis. It shows that the numbers of double strand breakages per DNA presented nonlinear feature as the concentration of DNA decreasing, and the dose rate had little influence on DNA damage.

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