Study of Trace Element Metabolism in Normal and Cancerous Mice Using Multitracer Technique

WANG Xiao; ZHANG Xiang; QIN Zhi; KONG Fu-quan; Zhao Kui

doi:10.11804/NuclPhysRev.25.03.300

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Article Navigation > Nuclear Physics Review > 2008 > 25(3): 300-304

WANG Xiao, ZHANG Xiang, QIN Zhi, KONG Fu-quan, Zhao Kui. Study of Trace Element Metabolism in Normal and Cancerous Mice Using Multitracer Technique[J]. Nuclear Physics Review, 2008, 25(3): 300-304. doi: 10.11804/NuclPhysRev.25.03.300

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WANG Xiao, ZHANG Xiang, QIN Zhi, KONG Fu-quan, Zhao Kui. Study of Trace Element Metabolism in Normal and Cancerous Mice Using Multitracer Technique[J]. Nuclear Physics Review, 2008, 25(3): 300-304. doi: 10.11804/NuclPhysRev.25.03.300

Study of Trace Element Metabolism in Normal and Cancerous Mice Using Multitracer Technique

doi: 10.11804/NuclPhysRev.25.03.300

1 China Institute of Atomic Energy, Beijing 102413, China; 2 Department of Chemistry, University of Louisville, Louisville, KY 40292, USA; 3 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2008-09-20

Abstract

A radioactive multitracer solution of the 24 elements, e.g. Be, Na, K, Rb, Mg, Ca, Sr, Ga, As, Sc, V, Cr, Mn, Co, Fe, Zn, Y, Zr, Mo, Nb, Tc, Ru, Ag and In, was obtained from the nuclear reaction of 25 MeV/u ⁴⁰Ar+Se with a series of chemical process. The multitracer solution was orally administered to normal and muscular tumourbearing mice of male Balb/c mice. Urine and faeces samples of mice were collected. The two group mice were sacrificed after 96 h. The uptake of 17 elements, Na, Rb, Ga, As, Sc, V, Cr, Mn, Co, Fe, Zn, Y, Zr, Tc, Ru, Ag and In, were simultaneously detected in normal mice while 15 elements, Na, Rb, Ga, Sc, V, Cr, Mn, Co, Fe, Y, Zr, Tc, Ru, Ag and In, were simultaneously detected in tumourbearing mice. Our results indicate that the majority of the detected elements were distributed in liver, kidney, pelt, tumour while a small fraction of the biotrace elements were distributed in heart and spleen (tumourbearing mice) in the two groups of mice. The higher concentrations of Fe, Na, Mn were detected in heart or kidney of normal mice. Na, Mn, Fe and Co showed better absorption in most tissues in the normal mice, except for Na and Mn in heart.
- multitracer,
- trace element,
- metabolism,
- cancerous mice
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Study of Trace Element Metabolism in Normal and Cancerous Mice Using Multitracer Technique

doi: 10.11804/NuclPhysRev.25.03.300

1 China Institute of Atomic Energy, Beijing 102413, China; 2 Department of Chemistry, University of Louisville, Louisville, KY 40292, USA; 3 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2008-09-20

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Abstract: A radioactive multitracer solution of the 24 elements, e.g. Be, Na, K, Rb, Mg, Ca, Sr, Ga, As, Sc, V, Cr, Mn, Co, Fe, Zn, Y, Zr, Mo, Nb, Tc, Ru, Ag and In, was obtained from the nuclear reaction of 25 MeV/u ⁴⁰Ar+Se with a series of chemical process. The multitracer solution was orally administered to normal and muscular tumourbearing mice of male Balb/c mice. Urine and faeces samples of mice were collected. The two group mice were sacrificed after 96 h. The uptake of 17 elements, Na, Rb, Ga, As, Sc, V, Cr, Mn, Co, Fe, Zn, Y, Zr, Tc, Ru, Ag and In, were simultaneously detected in normal mice while 15 elements, Na, Rb, Ga, Sc, V, Cr, Mn, Co, Fe, Y, Zr, Tc, Ru, Ag and In, were simultaneously detected in tumourbearing mice. Our results indicate that the majority of the detected elements were distributed in liver, kidney, pelt, tumour while a small fraction of the biotrace elements were distributed in heart and spleen (tumourbearing mice) in the two groups of mice. The higher concentrations of Fe, Na, Mn were detected in heart or kidney of normal mice. Na, Mn, Fe and Co showed better absorption in most tissues in the normal mice, except for Na and Mn in heart.

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