<SUP>99m</SUP>Tc Labeling of Carbon Nanomaterials

ZHU Ying; LI Yu-feng; ZHANG Xiao-yong; LI Qing-nuan; LI Wen-xin; #

doi:10.11804/NuclPhysRev.25.03.305

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ZHU Ying, LI Yu-feng, ZHANG Xiao-yong, LI Qing-nuan, LI Wen-xin, #. 99mTc Labeling of Carbon Nanomaterials[J]. Nuclear Physics Review, 2008, 25(3): 305-310. doi: 10.11804/NuclPhysRev.25.03.305

Citation:

ZHU Ying, LI Yu-feng, ZHANG Xiao-yong, LI Qing-nuan, LI Wen-xin, #. ^99mTc Labeling of Carbon Nanomaterials[J]. Nuclear Physics Review, 2008, 25(3): 305-310. doi: 10.11804/NuclPhysRev.25.03.305

^99mTc Labeling of Carbon Nanomaterials

doi: 10.11804/NuclPhysRev.25.03.305

1 Laboratory of Nanobiology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;2 Graduate School of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2008-09-20

Abstract

The effects of experimental conditions on preparation of ^99mTclabeled carbon nanotubes and nanocarbon blacks by SnCl2 were investigated. At given conditions the labeling yields were over 90%. In a culture medium， the radiochemical purity of the labeling compounds kept (86±4)% within 2.5 h. The 99mTc labeled multiwalled carbon nanotubes (MWNTs) and nanocarbon blackes (NCBs) obtained in this work met satisfactory experimental demands for study of cellular uptake and toxicity. The experiments showed that the labeling process was based on physical adsorption of low valent technetium resulted from reduction reaction on the surface of the carbon nanomaterials.
- ^99mTc labeling,
- multiwalled carbon nanotube,
- nanocarbon black
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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^99mTc Labeling of Carbon Nanomaterials

doi: 10.11804/NuclPhysRev.25.03.305

1 Laboratory of Nanobiology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China;2 Graduate School of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2008-09-20

Key words:

Abstract: The effects of experimental conditions on preparation of ^99mTclabeled carbon nanotubes and nanocarbon blacks by SnCl2 were investigated. At given conditions the labeling yields were over 90%. In a culture medium， the radiochemical purity of the labeling compounds kept (86±4)% within 2.5 h. The 99mTc labeled multiwalled carbon nanotubes (MWNTs) and nanocarbon blackes (NCBs) obtained in this work met satisfactory experimental demands for study of cellular uptake and toxicity. The experiments showed that the labeling process was based on physical adsorption of low valent technetium resulted from reduction reaction on the surface of the carbon nanomaterials.

ZHU Ying, LI Yu-feng, ZHANG Xiao-yong, LI Qing-nuan, LI Wen-xin, #. 99mTc Labeling of Carbon Nanomaterials[J]. Nuclear Physics Review, 2008, 25(3): 305-310. doi: 10.11804/NuclPhysRev.25.03.305

Citation:

ZHU Ying, LI Yu-feng, ZHANG Xiao-yong, LI Qing-nuan, LI Wen-xin, #. ^99mTc Labeling of Carbon Nanomaterials[J]. Nuclear Physics Review, 2008, 25(3): 305-310. doi: 10.11804/NuclPhysRev.25.03.305