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Article Navigation >  Nuclear Physics Review  > 2010  >  27(2): 202-205

Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202
Citation: Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202
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A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation

doi: 10.11804/NuclPhysRev.27.02.202

  • 1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;3 Graduate University of Chinese Academy of Sciences, Beijing 100049, China

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2010-06-20
  • It has been proven that over expression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study，action mechanisms of survivin gene in apoptosis induced by high LET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.
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A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation

doi: 10.11804/NuclPhysRev.27.02.202
  • 1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;2 Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;3 Graduate University of Chinese Academy of Sciences, Beijing 100049, China
  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2010-06-20

Abstract: It has been proven that over expression of survivin in cancerous cell lines is related to the radioresistance of cells to highLET radiation in previous work. In this study，action mechanisms of survivin gene in apoptosis induced by high LET radiation were investigated. We found that inhibiting survivin by siRNA had no notable influence on Bcl-2 and Bax expressions induced by carbon ions. Survivin depressed cell apoptosis through the inhibition of the activities of caspase-3 and -9 possibly in cell apoptosis induced by highLET radiation.

Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202
Citation: Jin Xiao-dong, LI Qiang, WU Qing-feng, LI Ping, TAO Jia-jun, GONG Li, DAI Zhong-ying, LIU Xin-guo. A Preliminary Study on Action Mechanisms of Survivin Expression in Cell Apoptosis Induced by HighLET Radiation[J]. Nuclear Physics Review, 2010, 27(2): 202-205. doi: 10.11804/NuclPhysRev.27.02.202
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