Beam Intensity Map Optimization Based on Conjugate Gradient in Intensity Modulated Radiation Treatment

Key words: 
• objective function /
• intensity modulated radiation treatment /
• intensity map

Abstract: The beam intensity map optimization of Intensity Modulated Radiation Treatment(IMRT) is a large scale optimization problem because of thousands of parameters involved. A fast and efficient approach was studied in the paper according to the clinical requirement for high speed and good results. Firstly, the clinical prescribed dose of Planning Target Volume(PTV) and dosevolume constraints of Normal Tissue and Organ at Risk(OAR) were transformed into a quadratic objective function. And then Conjugate Gradient(CG) was adopted to optimize the objective function. At last, a simulated case and a clinical case were used to test the approach. The results showed that the optimization process need 40 s while satisfied results could be obtained in 10 s for simulated case and the optimization process need 1 min and 20 s while optimized results could be obtained in 20 s for the clinical prostate case. So it can be found that the approach of proposed in this paper is valid and efficient, and can be used to the accurate radiation therapy system.