Investigation on Radiation Dose and Histopathological Evaluation of ¹⁸⁸Re inner Irradiation in Mouse Transplanted Tumor H₂₂

Key words: 
• ¹⁸⁸Re /
• hepatocellular carcinoma /
• antitumor /
• internal radiation dose /
• histopathology

Abstract: The retention of the radioactive nuclide 188Re in tumor was measured in 1h and 24 h after injection of 188Re and 188ReS, respectively. The results indicate that the radionuclide remained in the tumor injected 188ReS was higher than that in the tumor of injected 188Re. Pathology test results show that in the model group one can find obviously the rapid growth of tumor cells and rich tumor angiogenesis; in the treatment groups the tumor growth is constrained in different degrees, microvascular was less and the necrosis area was spreading from the periphery to the center of the tumor. Scanning the samples of the tumors treated by 0.1 mCi 188ReS injection by using SEM shows there is a lot of apoptotic bodies of tumor cells. The injection of 188ReS into the tumor can be an effective target treatment source for therapy to decrease the radiation dosage in whole body and to reduce the toxicity side effects.