Progress  of Research  on  Ionizing  Radiationinduced Bystander  Effects  in  <EM>vivo</EM>

LIANG  Shu-jian; ZHANG  Meng; LI  Wen-jian; JING  Xi-gang; SUN  Ye-qing; #

doi:10.11804/NuclPhysRev.28.02.230

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Article Navigation > Nuclear Physics Review > 2011 > 28(2): 230-235

LIANG Shu-jian, ZHANG Meng, LI Wen-jian, JING Xi-gang, SUN Ye-qing, #. Progress of Research on Ionizing Radiationinduced Bystander Effects in vivo[J]. Nuclear Physics Review, 2011, 28(2): 230-235. doi: 10.11804/NuclPhysRev.28.02.230

Citation:

LIANG Shu-jian, ZHANG Meng, LI Wen-jian, JING Xi-gang, SUN Ye-qing, #. Progress of Research on Ionizing Radiationinduced Bystander Effects in vivo[J]. Nuclear Physics Review, 2011, 28(2): 230-235. doi: 10.11804/NuclPhysRev.28.02.230

Progress of Research on Ionizing Radiationinduced Bystander Effects in vivo

doi: 10.11804/NuclPhysRev.28.02.230

1 School of Astronautics, Harbin Institute of Technology, Harbin 150001, China; 2 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 3 Institute of Environmental System Biology, Dalian Maritime University, Dalian 116026, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2011-06-20

Abstract

Radiationinduced bystander effect is defined as the induction of damage in neighboring nonhit cells by signals released from directlyirradiated cells. ROS， NO and cytokines are involved in signaling pathways of bystander effects. Recently， the bystander effects in vivo have been reported more and more. It has been indicated that radiation induced bystander effect was localized not only in bystander tissues but also in distant organs. This effect includes many biological endpoints such as DNA damage， epigenetic， miRNA and gene expression changes， cell proliferation and apoptosis. In this review we described different aspects of ionizing radiationinduced bystander effects such as its characteristics， sex specific， signaling transfer， dose and LET dependence， and related mechanisms.
- radiation,
- bystander effect,
- in vivo,
- epigenetic
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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Progress of Research on Ionizing Radiationinduced Bystander Effects in vivo

doi: 10.11804/NuclPhysRev.28.02.230

1 School of Astronautics, Harbin Institute of Technology, Harbin 150001, China; 2 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 3 Institute of Environmental System Biology, Dalian Maritime University, Dalian 116026, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2011-06-20

Key words:

Abstract: Radiationinduced bystander effect is defined as the induction of damage in neighboring nonhit cells by signals released from directlyirradiated cells. ROS， NO and cytokines are involved in signaling pathways of bystander effects. Recently， the bystander effects in vivo have been reported more and more. It has been indicated that radiation induced bystander effect was localized not only in bystander tissues but also in distant organs. This effect includes many biological endpoints such as DNA damage， epigenetic， miRNA and gene expression changes， cell proliferation and apoptosis. In this review we described different aspects of ionizing radiationinduced bystander effects such as its characteristics， sex specific， signaling transfer， dose and LET dependence， and related mechanisms.

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