Influence of Modeled Microgravity on Mouse Reproductive Organs Induced by Carbonion Beams

ZHANG Lu-wei; LIU Yang; ZHANG Hong<SUB>; #</SUB>; WANG Zheng-hua;  WU Zheng-hua; ZHAO Wei-ping

doi:10.11804/NuclPhysRev.28.03.337

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Article Navigation > Nuclear Physics Review > 2011 > 28(3): 337-342

ZHANG Lu-wei, LIU Yang, ZHANG Hong, #, WANG Zheng-hua,  WU Zheng-hua, ZHAO Wei-ping, . Influence of Modeled Microgravity on Mouse Reproductive Organs Induced by Carbonion Beams[J]. Nuclear Physics Review, 2011, 28(3): 337-342. doi: 10.11804/NuclPhysRev.28.03.337

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ZHANG Lu-wei, LIU Yang, ZHANG Hong_{, #}, WANG Zheng-hua,  WU Zheng-hua, ZHAO Wei-ping, . Influence of Modeled Microgravity on Mouse Reproductive Organs Induced by Carbonion Beams[J]. Nuclear Physics Review, 2011, 28(3): 337-342. doi: 10.11804/NuclPhysRev.28.03.337

Influence of Modeled Microgravity on Mouse Reproductive Organs Induced by Carbonion Beams

doi: 10.11804/NuclPhysRev.28.03.337

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2 Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; 3 Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China; 4 Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2011-09-20

Abstract

In this paper it was investigated that the effect of modeled microgravity on the acute injury induced by low doses of carbon ions in the male reproductive organs of mice, assessing the risk associated with the space environments. In our study, outbred Kunming mice were stimulated in microgravity by tail suspension, and then were irradiated with the low doses of carbon ions diliuered by HIRFL, and measured the testis and epididymis coefficient, sperm number of epididymis, histological alterations, DNA strand breaks and cell apoptosis. The results demonstrated that carbon ions and stimulated microgravity could induce the damage in the present study. Moreover, most serious injury all occurred in the irradiation group. In addition, it was also found that the damage of the carbon ion irradiation combined microgravity group were lower than those of the irradiation group, while the related mechanism needs the further investigation.
- modeled microgravity,
- Carbon ion irradiation,
- acute damage,
- testis,
- mouse
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Influence of Modeled Microgravity on Mouse Reproductive Organs Induced by Carbonion Beams

doi: 10.11804/NuclPhysRev.28.03.337

1 Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; 2 Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; 3 Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China; 4 Graduate University of Chinese Academy of Sciences, Beijing 100049, China

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2011-09-20

Key words:

Abstract: In this paper it was investigated that the effect of modeled microgravity on the acute injury induced by low doses of carbon ions in the male reproductive organs of mice, assessing the risk associated with the space environments. In our study, outbred Kunming mice were stimulated in microgravity by tail suspension, and then were irradiated with the low doses of carbon ions diliuered by HIRFL, and measured the testis and epididymis coefficient, sperm number of epididymis, histological alterations, DNA strand breaks and cell apoptosis. The results demonstrated that carbon ions and stimulated microgravity could induce the damage in the present study. Moreover, most serious injury all occurred in the irradiation group. In addition, it was also found that the damage of the carbon ion irradiation combined microgravity group were lower than those of the irradiation group, while the related mechanism needs the further investigation.

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