Culture of Threedimensional Tissue Model and Its Application in Bystandereffect Research

WU Ru-qun; XU An; WU Li-jun; HU Bu-rong

doi:10.11804/NuclPhysRev.29.01.097

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Article Navigation > Nuclear Physics Review > 2012 > 29(1): 97-102

WU Ru-qun, XU An, WU Li-jun, HU Bu-rong. Culture of Threedimensional Tissue Model and Its Application in Bystandereffect Research[J]. Nuclear Physics Review, 2012, 29(1): 97-102. doi: 10.11804/NuclPhysRev.29.01.097

Citation:

WU Ru-qun, XU An, WU Li-jun, HU Bu-rong. Culture of Threedimensional Tissue Model and Its Application in Bystandereffect Research[J]. Nuclear Physics Review, 2012, 29(1): 97-102. doi: 10.11804/NuclPhysRev.29.01.097

Culture of Threedimensional Tissue Model and Its Application in Bystandereffect Research

doi: 10.11804/NuclPhysRev.29.01.097

Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2012-03-20

Abstract

Compared with the cultured monolayer (2D) cells， threedimensional (3D) tissue could be more similar to the environment in vivo including the physical support， chemical factors， cellcell and cellmatrix interaction and so on. With the development of threedimensional cell culture techniques (TDCC)， 3D tissue is widely used in the areas of bystander effect research. This review focuses on introducing the TDCC method and its application in bystandereffect research. First， the development process of 3D tissue culture method was introduced. Secondly， the induction of radiation induced bystander effects both in 2D cell and 3D tissue and its mechanisms were reviewed. Finally， because heavy ion (carbon ion beam) has been developed as a useful tool to cure solid cancer ，and the 3D tissue model is an ideal material to study the damages on body after being irradiated and to understand the underlying mechanisms， future study about heavy ion radiation inducing bystander effect in 3D tissue was discussed.
- threedimensional (3D) tissue model,
- radiation,
- bystander effect
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Culture of Threedimensional Tissue Model and Its Application in Bystandereffect Research

doi: 10.11804/NuclPhysRev.29.01.097

Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2012-03-20

Key words:

Abstract: Compared with the cultured monolayer (2D) cells， threedimensional (3D) tissue could be more similar to the environment in vivo including the physical support， chemical factors， cellcell and cellmatrix interaction and so on. With the development of threedimensional cell culture techniques (TDCC)， 3D tissue is widely used in the areas of bystander effect research. This review focuses on introducing the TDCC method and its application in bystandereffect research. First， the development process of 3D tissue culture method was introduced. Secondly， the induction of radiation induced bystander effects both in 2D cell and 3D tissue and its mechanisms were reviewed. Finally， because heavy ion (carbon ion beam) has been developed as a useful tool to cure solid cancer ，and the 3D tissue model is an ideal material to study the damages on body after being irradiated and to understand the underlying mechanisms， future study about heavy ion radiation inducing bystander effect in 3D tissue was discussed.

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