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Article Navigation >  Nuclear Physics Review  > 2012  >  29(2): 196-201

YANG Li-na, ZHANG Hong, DI Cui-xia, ZHANG Qiu-ning, WANG Xiao-hu. Progress on Clustered DNA Damage in Radiation Research[J]. Nuclear Physics Review, 2012, 29(2): 196-201. doi: 10.11804/NuclPhysRev.29.02.196
Citation: YANG Li-na, ZHANG Hong, DI Cui-xia, ZHANG Qiu-ning, WANG Xiao-hu. Progress on Clustered DNA Damage in Radiation Research[J]. Nuclear Physics Review, 2012, 29(2): 196-201. doi: 10.11804/NuclPhysRev.29.02.196
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Progress on Clustered DNA Damage in Radiation Research

doi: 10.11804/NuclPhysRev.29.02.196
  • 1.

    School of Life Sciences, Lanzhou University, Lanzhou 730000, China;2.Gansu Academy of Medical Sciences, Lanzhou 730000, China;3.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;4.Key Laboratories of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2012-06-20
  • Clustered DNA damage which caused by high LET heavy ion radiation can lead to mutation, tumorigenesis and apoptosis. Promoting apoptosis of cancer cells is always the basis of cancer treatment. Clustered DNA damage has been the hot topic in radiobiology. The detect method is diversity, but there is not a detail and complete protocol to analyze clustered DNA damage. In order to provide reference for clustered DNA damage in the radiotherapy study, the clustered DNA damage characteristics, the latest progresses on clustered DNA damage and the detecting methods are reviewed and discussed in deteil in this paper.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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Progress on Clustered DNA Damage in Radiation Research

doi: 10.11804/NuclPhysRev.29.02.196
  • 1. School of Life Sciences, Lanzhou University, Lanzhou 730000, China;2.Gansu Academy of Medical Sciences, Lanzhou 730000, China;3.Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;4.Key Laboratories of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China
  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2012-06-20

Abstract: Clustered DNA damage which caused by high LET heavy ion radiation can lead to mutation, tumorigenesis and apoptosis. Promoting apoptosis of cancer cells is always the basis of cancer treatment. Clustered DNA damage has been the hot topic in radiobiology. The detect method is diversity, but there is not a detail and complete protocol to analyze clustered DNA damage. In order to provide reference for clustered DNA damage in the radiotherapy study, the clustered DNA damage characteristics, the latest progresses on clustered DNA damage and the detecting methods are reviewed and discussed in deteil in this paper.

YANG Li-na, ZHANG Hong, DI Cui-xia, ZHANG Qiu-ning, WANG Xiao-hu. Progress on Clustered DNA Damage in Radiation Research[J]. Nuclear Physics Review, 2012, 29(2): 196-201. doi: 10.11804/NuclPhysRev.29.02.196
Citation: YANG Li-na, ZHANG Hong, DI Cui-xia, ZHANG Qiu-ning, WANG Xiao-hu. Progress on Clustered DNA Damage in Radiation Research[J]. Nuclear Physics Review, 2012, 29(2): 196-201. doi: 10.11804/NuclPhysRev.29.02.196
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