Inhibitory Effect of <SUP>12</SUP>C<SUP>6+</SUP> Ion and X-ray on Angiogenesis in HMEC-1

LIU Yuan-yuan; ZHANG Hong; LIU Yang; SUN Chao; WU Zhen-hua; LI Hong-yan

doi:10.11804/NuclPhysRev.30.01.084

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Article Navigation > Nuclear Physics Review > 2013 > 30(1): 84-88

LIU Yuan-yuan, ZHANG Hong, LIU Yang, SUN Chao, WU Zhen-hua, LI Hong-yan. Inhibitory Effect of 12C6+ Ion and X-ray on Angiogenesis in HMEC-1[J]. Nuclear Physics Review, 2013, 30(1): 84-88. doi: 10.11804/NuclPhysRev.30.01.084

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LIU Yuan-yuan, ZHANG Hong, LIU Yang, SUN Chao, WU Zhen-hua, LI Hong-yan. Inhibitory Effect of ¹²C⁶⁺ Ion and X-ray on Angiogenesis in HMEC-1[J]. Nuclear Physics Review, 2013, 30(1): 84-88. doi: 10.11804/NuclPhysRev.30.01.084

Inhibitory Effect of ¹²C⁶⁺ Ion and X-ray on Angiogenesis in HMEC-1

doi: 10.11804/NuclPhysRev.30.01.084

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;
Key Laboratory of Heavy Ion Radiation Biology and Medicine of Gansu Province, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2013-03-20

Abstract

The study aims to explore the effect of ¹²C⁶⁺ion and X-ray on proliferation, migration, tube formation and MMPS of human microvascular endothelial cells ( HMEC-1 ). Transwell migration experiment showed that the radiation could inhibit the migration of HMEC-1 in sub-lethal dose 24 h after irradiation. Furthermore, the inhibition ability of 12C6+ ion was stronger than that of X-ray. Matrigel experiment indicated that ¹²C⁶⁺ ion suppressed the tube formation of HMEC-1 spontaneously. However, the inhibitory effect of X-ray had no significance. Meanwhile, Gelatin Zymography showed the expression of MMP-2 was inhibited obviously by ¹²C⁶⁺ ion, while X-ray had little effect on the expression of MMP-2. In conclusion, ¹²C⁶⁺ion is superior to X-ray in adiotherapy of tumor.
- heavy ion,
- X-ray,
- radiation,
- angiogenesis,
- cancer
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Inhibitory Effect of ¹²C⁶⁺ Ion and X-ray on Angiogenesis in HMEC-1

doi: 10.11804/NuclPhysRev.30.01.084

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Biology and Medicine of Gansu Province, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2013-03-20

Key words:

heavy ion /
X-ray /
radiation /
angiogenesis /
cancer

Abstract: The study aims to explore the effect of ¹²C⁶⁺ion and X-ray on proliferation, migration, tube formation and MMPS of human microvascular endothelial cells ( HMEC-1 ). Transwell migration experiment showed that the radiation could inhibit the migration of HMEC-1 in sub-lethal dose 24 h after irradiation. Furthermore, the inhibition ability of 12C6+ ion was stronger than that of X-ray. Matrigel experiment indicated that ¹²C⁶⁺ ion suppressed the tube formation of HMEC-1 spontaneously. However, the inhibitory effect of X-ray had no significance. Meanwhile, Gelatin Zymography showed the expression of MMP-2 was inhibited obviously by ¹²C⁶⁺ ion, while X-ray had little effect on the expression of MMP-2. In conclusion, ¹²C⁶⁺ion is superior to X-ray in adiotherapy of tumor.

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Inhibitory Effect of 12C6+ Ion and X-ray on Angiogenesis in HMEC-1

doi: 10.11804/NuclPhysRev.30.01.084

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通讯作者: 陈斌, bchen63@163.com

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Inhibitory Effect of 12C6+ Ion and X-ray on Angiogenesis in HMEC-1

doi: 10.11804/NuclPhysRev.30.01.084

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou 730000, China; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Gansu Province, Lanzhou 730000, China;

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Inhibitory Effect of ¹²C⁶⁺ Ion and X-ray on Angiogenesis in HMEC-1

Inhibitory Effect of ¹²C⁶⁺ Ion and X-ray on Angiogenesis in HMEC-1

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Biology and Medicine of Gansu Province, Lanzhou 730000, China;