Hypoxia Mitochondria and Tumor Radiation Resistance

HE Yang; ZHOU Xin; ZHANG Hong

doi:10.11804/NuclPhysRev.30.04.488

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HE Yang, ZHOU Xin, ZHANG Hong. Hypoxia Mitochondria and Tumor Radiation Resistance[J]. Nuclear Physics Review, 2013, 30(4): 488-493. doi: 10.11804/NuclPhysRev.30.04.488

Citation:

HE Yang, ZHOU Xin, ZHANG Hong. Hypoxia Mitochondria and Tumor Radiation Resistance[J]. Nuclear Physics Review, 2013, 30(4): 488-493. doi: 10.11804/NuclPhysRev.30.04.488

Hypoxia Mitochondria and Tumor Radiation Resistance

doi: 10.11804/NuclPhysRev.30.04.488

Institute of Modern Physics , Chinese Academy of Sciences, Lanzhou 730000, China;
Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;
Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2013-12-20

Abstract

The hypoxia environment on the cells and mitochondria, and the damage of normal cells mitochondrial respiratory chain in hypoxia and its relationship with tumors are reviewed. In addition, the tumor radiation resistance mechanism in hypoxia are summarized. It also expounds that mitochondria, as energy supply organelles for cells, are related to tumor cells growth, invasion and metastasis in hypoxia environment, besides, it gives a brief introduction to the mitochondria study of the Institute of Modern Physics, Chinese Academy of Sciences with heavy ion irradiation, including effects of different dose of heavy ion on mitochondrial DNA superhelix conformation and function of mitochondria,
and the influence on mitochondrial DNA 4 977 damage cumulation in different time after the same dose of heavy ion irradiation.
- hypoxia,
- mitochondria,
- tumor,
- radiation resistance
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Hypoxia Mitochondria and Tumor Radiation Resistance

doi: 10.11804/NuclPhysRev.30.04.488

Institute of Modern Physics , Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2013-12-20

Key words:

Abstract: The hypoxia environment on the cells and mitochondria, and the damage of normal cells mitochondrial respiratory chain in hypoxia and its relationship with tumors are reviewed. In addition, the tumor radiation resistance mechanism in hypoxia are summarized. It also expounds that mitochondria, as energy supply organelles for cells, are related to tumor cells growth, invasion and metastasis in hypoxia environment, besides, it gives a brief introduction to the mitochondria study of the Institute of Modern Physics, Chinese Academy of Sciences with heavy ion irradiation, including effects of different dose of heavy ion on mitochondrial DNA superhelix conformation and function of mitochondria,
and the influence on mitochondrial DNA 4 977 damage cumulation in different time after the same dose of heavy ion irradiation.

HE Yang, ZHOU Xin, ZHANG Hong. Hypoxia Mitochondria and Tumor Radiation Resistance[J]. Nuclear Physics Review, 2013, 30(4): 488-493. doi: 10.11804/NuclPhysRev.30.04.488

Citation:

HE Yang, ZHOU Xin, ZHANG Hong. Hypoxia Mitochondria and Tumor Radiation Resistance[J]. Nuclear Physics Review, 2013, 30(4): 488-493. doi: 10.11804/NuclPhysRev.30.04.488