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Article Navigation >  Nuclear Physics Review  > 2014  >  31(1): 101-105

ZHAO Qiuyue, WANG Zhenhua, XIE Yi, XU Shuai, DI Cuixia, ZHANG Hong. Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
Citation: ZHAO Qiuyue, WANG Zhenhua, XIE Yi, XU Shuai, DI Cuixia, ZHANG Hong. Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
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Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams

doi: 10.11804/NuclPhysRev.31.01.101

  • Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

  • Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,Lanzhou 730000, China;

  • Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China;

  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2014-03-20
  • The protective effect of Curcumin (Cur) against the irradiation damage of testis in mice induced by 12C6+ ion beams was studied. Male Kung-Ming mice were exposed to whole body uniformly irradiated with 12C6+ ion beams at 4 Gy after pretreated with Cur of different concentration. Then histological alterations were observed. Moreover, malonaldehyde (MDA) level, superoxide dismutase (SOD) activity and catalase (CAT) activity were also measured at 24 h after irradiation. The result showed that middle and high dose Cur pretreated have a good protective effect. Compared with irradiated group, MDA level decreased dramatically in the group of pretreatment with low and middle dose Cur (P < 0:05). On the contrary, SOD activity in the pretreated group with low dose Cur significantly increased (P <0:05). Similarly, CAT activity in the pretreated group with middle dose Cur significantly increased (P <0:05). Data suggested that Cur could activate antioxidant system of testis in mice induced by12C6+ ion beams, it have some protective effect to radiation damage. The mechanism may involve in its scavenging reactive oxidant species and thenprotecting lipid and protein capability.
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Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams

doi: 10.11804/NuclPhysRev.31.01.101
  • Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
  • Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences,Lanzhou 730000, China;
  • Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China;
  • Received Date: 1900-01-01
  • Rev Recd Date: 1900-01-01
  • Publish Date: 2014-03-20

Abstract: The protective effect of Curcumin (Cur) against the irradiation damage of testis in mice induced by 12C6+ ion beams was studied. Male Kung-Ming mice were exposed to whole body uniformly irradiated with 12C6+ ion beams at 4 Gy after pretreated with Cur of different concentration. Then histological alterations were observed. Moreover, malonaldehyde (MDA) level, superoxide dismutase (SOD) activity and catalase (CAT) activity were also measured at 24 h after irradiation. The result showed that middle and high dose Cur pretreated have a good protective effect. Compared with irradiated group, MDA level decreased dramatically in the group of pretreatment with low and middle dose Cur (P < 0:05). On the contrary, SOD activity in the pretreated group with low dose Cur significantly increased (P <0:05). Similarly, CAT activity in the pretreated group with middle dose Cur significantly increased (P <0:05). Data suggested that Cur could activate antioxidant system of testis in mice induced by12C6+ ion beams, it have some protective effect to radiation damage. The mechanism may involve in its scavenging reactive oxidant species and thenprotecting lipid and protein capability.

ZHAO Qiuyue, WANG Zhenhua, XIE Yi, XU Shuai, DI Cuixia, ZHANG Hong. Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
Citation: ZHAO Qiuyue, WANG Zhenhua, XIE Yi, XU Shuai, DI Cuixia, ZHANG Hong. Study on Protective Effect of Curcumin against the Irradiation Damage of Testis in Mice Induced by 12C6+ Ion Beams[J]. Nuclear Physics Review, 2014, 31(1): 101-105. doi: 10.11804/NuclPhysRev.31.01.101
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