Research on Cellular Senescence Induced by Heavy Ion

YE Caiyong; ZHANG Yanan; WANG Jufang; ZHOU Guangming

doi:10.11804/NuclPhysRev.31.02.201

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YE Caiyong, ZHANG Yanan, WANG Jufang, ZHOU Guangming. Research on Cellular Senescence Induced by Heavy Ion[J]. Nuclear Physics Review, 2014, 31(2): 201-209. doi: 10.11804/NuclPhysRev.31.02.201

Citation:

YE Caiyong, ZHANG Yanan, WANG Jufang, ZHOU Guangming. Research on Cellular Senescence Induced by Heavy Ion[J]. Nuclear Physics Review, 2014, 31(2): 201-209. doi: 10.11804/NuclPhysRev.31.02.201

Research on Cellular Senescence Induced by Heavy Ion

doi: 10.11804/NuclPhysRev.31.02.201

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
Key Laboratory of Heavy Ion Radiation Biology and Medicine of ChineseAcademy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2014-06-20

Abstract

Cellular senescence played double roles in the genesis and development of cancer, which was put forward through reviewing the cases and characteristics of cellular senescence. In addition, human uveal melanoma cells and human fetal lung broblast (MRC5) cells were irradiated by X-rays or ¹²C⁶⁺ ion beam. DNA damage response (DDR) and cellular senescence were analyzed. The results showed that DDR was activated persistently by the unrepairable clustered DNA damage, which indicated that inducing same ratios of cellular senescence needed lower doses of 12C6+ ion beam than X-rays. Furthermore, both 92-1 cells and MRC5 cells treated by carbon ion beam underwent cellular senescence. These results pointed out the urgency to investigate the mechanism of cellular senescence induced by ¹²C⁶⁺ ion beam.
- cellular senescence,
- tumorigenesis,
- clustered DNA damage,
- carbon ion beam
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Research on Cellular Senescence Induced by Heavy Ion

doi: 10.11804/NuclPhysRev.31.02.201

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Biology and Medicine of ChineseAcademy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2014-06-20

Key words:

Abstract: Cellular senescence played double roles in the genesis and development of cancer, which was put forward through reviewing the cases and characteristics of cellular senescence. In addition, human uveal melanoma cells and human fetal lung broblast (MRC5) cells were irradiated by X-rays or ¹²C⁶⁺ ion beam. DNA damage response (DDR) and cellular senescence were analyzed. The results showed that DDR was activated persistently by the unrepairable clustered DNA damage, which indicated that inducing same ratios of cellular senescence needed lower doses of 12C6+ ion beam than X-rays. Furthermore, both 92-1 cells and MRC5 cells treated by carbon ion beam underwent cellular senescence. These results pointed out the urgency to investigate the mechanism of cellular senescence induced by ¹²C⁶⁺ ion beam.

YE Caiyong, ZHANG Yanan, WANG Jufang, ZHOU Guangming. Research on Cellular Senescence Induced by Heavy Ion[J]. Nuclear Physics Review, 2014, 31(2): 201-209. doi: 10.11804/NuclPhysRev.31.02.201

Citation:

YE Caiyong, ZHANG Yanan, WANG Jufang, ZHOU Guangming. Research on Cellular Senescence Induced by Heavy Ion[J]. Nuclear Physics Review, 2014, 31(2): 201-209. doi: 10.11804/NuclPhysRev.31.02.201