Research on the Radiosensitizing Effect of Gold Nanoparticles

LIU Xi; LIU Yan; CHEN Weiqiang; LI Qiang

doi:10.11804/NuclPhysRev.32.02.230

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Volume 32 Issue 2

Jun. 2015

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Article Navigation > Nuclear Physics Review > 2015 > 32(2): 230-235

LIU Xi, LIU Yan, CHEN Weiqiang, LI Qiang. Research on the Radiosensitizing Effect of Gold Nanoparticles[J]. Nuclear Physics Review, 2015, 32(2): 230-235. doi: 10.11804/NuclPhysRev.32.02.230

Citation:

LIU Xi, LIU Yan, CHEN Weiqiang, LI Qiang. Research on the Radiosensitizing Effect of Gold Nanoparticles[J]. Nuclear Physics Review, 2015, 32(2): 230-235. doi: 10.11804/NuclPhysRev.32.02.230

Research on the Radiosensitizing Effect of Gold Nanoparticles

doi: 10.11804/NuclPhysRev.32.02.230

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2015-06-20

Abstract

This paper describes the methods and results of the previous experiments, the experimental phenomena of the cell and animal tests and the relative mechanisms on the radiosensitizing effect of GNPs. Together with our experiments, the radiosensitizing effects of 15 nm citrate-capped GNPs and related mechanisms are analyzed and compared, finding that Hela cell killing of GNPs increase along with their concentration after exposure to high- and low-LET radiation such as carbon ions and X-rays. In addition, the percentages of dose reduction of the X-rays and RBE increment of the carbon ions reached their maximums 65.3% and 43.6%, respectively,at 50% survival level when Hela cells were pre-treated with 7.5 g/mL GNPs. Moreover, Hela cells showed no cell-cycle synchronization after 24 and 48 h exposure to GNPs.
- gold nanoparticles,
- radiosensitizing effect,
- tumor therapy
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Research on the Radiosensitizing Effect of Gold Nanoparticles

doi: 10.11804/NuclPhysRev.32.02.230

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2015-06-20

Key words:

Abstract: This paper describes the methods and results of the previous experiments, the experimental phenomena of the cell and animal tests and the relative mechanisms on the radiosensitizing effect of GNPs. Together with our experiments, the radiosensitizing effects of 15 nm citrate-capped GNPs and related mechanisms are analyzed and compared, finding that Hela cell killing of GNPs increase along with their concentration after exposure to high- and low-LET radiation such as carbon ions and X-rays. In addition, the percentages of dose reduction of the X-rays and RBE increment of the carbon ions reached their maximums 65.3% and 43.6%, respectively,at 50% survival level when Hela cells were pre-treated with 7.5 g/mL GNPs. Moreover, Hela cells showed no cell-cycle synchronization after 24 and 48 h exposure to GNPs.

LIU Xi, LIU Yan, CHEN Weiqiang, LI Qiang. Research on the Radiosensitizing Effect of Gold Nanoparticles[J]. Nuclear Physics Review, 2015, 32(2): 230-235. doi: 10.11804/NuclPhysRev.32.02.230

Citation:

LIU Xi, LIU Yan, CHEN Weiqiang, LI Qiang. Research on the Radiosensitizing Effect of Gold Nanoparticles[J]. Nuclear Physics Review, 2015, 32(2): 230-235. doi: 10.11804/NuclPhysRev.32.02.230