Effect of Endoplasmic Reticulum Stress on the Response of HeLa Cells to Carbon Ion Radiation

XIA Jiefang; WANG Zhuanzi; WEI Wei; DANG Bingrong; LI Wenjian

doi:10.11804/NuclPhysRev.32.02.236

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Volume 32 Issue 2

Jun. 2015

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Article Navigation > Nuclear Physics Review > 2015 > 32(2): 236-241

XIA Jiefang, WANG Zhuanzi, WEI Wei, DANG Bingrong, LI Wenjian. Effect of Endoplasmic Reticulum Stress on the Response of HeLa Cells to Carbon Ion Radiation[J]. Nuclear Physics Review, 2015, 32(2): 236-241. doi: 10.11804/NuclPhysRev.32.02.236

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XIA Jiefang, WANG Zhuanzi, WEI Wei, DANG Bingrong, LI Wenjian. Effect of Endoplasmic Reticulum Stress on the Response of HeLa Cells to Carbon Ion Radiation[J]. Nuclear Physics Review, 2015, 32(2): 236-241. doi: 10.11804/NuclPhysRev.32.02.236

Effect of Endoplasmic Reticulum Stress on the Response of HeLa Cells to Carbon Ion Radiation

doi: 10.11804/NuclPhysRev.32.02.236

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2015-06-20

Abstract

To investigate the effect of endoplasmic reticulum stress on HeLa cells to 12C6+ ion irradiation,HeLa cells were pretreated with 2.5 mmol/L dithiothreitol and irradiated by 12C6+ ions with different doses.The results showed that, compared with IR alone, dithiothreitol combined with carbon ion irradiation caused HeLa cell survival decreased, and the apoptosis increased. Moreover, dithiothreitol and carbon ion radiation combination treatment led to a significant increase of G2/M phase, and autophagy was activated obviously in combination treatment group. The results imply that continuous endoplasmic reticulum stress can change the response of HeLa cells to 12C6+ irradiation, and dithiothreitol may affect HeLa cells through the autophagy cell death pathway.
- 12C6+ ion radiation,
- dithiothreitol,
- survival and apoptosis,
- cell cycle,
- autophagy
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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Effect of Endoplasmic Reticulum Stress on the Response of HeLa Cells to Carbon Ion Radiation

doi: 10.11804/NuclPhysRev.32.02.236

Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

Received Date: 1900-01-01
Rev Recd Date: 1900-01-01
Publish Date: 2015-06-20

Key words:

Abstract: To investigate the effect of endoplasmic reticulum stress on HeLa cells to 12C6+ ion irradiation,HeLa cells were pretreated with 2.5 mmol/L dithiothreitol and irradiated by 12C6+ ions with different doses.The results showed that, compared with IR alone, dithiothreitol combined with carbon ion irradiation caused HeLa cell survival decreased, and the apoptosis increased. Moreover, dithiothreitol and carbon ion radiation combination treatment led to a significant increase of G2/M phase, and autophagy was activated obviously in combination treatment group. The results imply that continuous endoplasmic reticulum stress can change the response of HeLa cells to 12C6+ irradiation, and dithiothreitol may affect HeLa cells through the autophagy cell death pathway.

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