Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy

JI Tengfei; LIU Xinguo; DAI Zhongying; HE Pengbo; YAN Yuanlin; HUANG Qiyan; LI Qiang

doi:10.11804/NuclPhysRev.33.03.345

In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.

Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy

1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

2. Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

3. Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China;

4. University of Chinese Academy of Sciences, Beijing 100049, China

Funds: NSFC-CAS Joint Fund for Research Based on Large-scaled Scientific Facilities (U1232207); National Natural Science Foundation of China (11205217, 11475231, 11075191); National Key Technology Support Program of the Ministry of Science and Technology of China (2015BAI01B11)

Received Date: 2015-09-18

Rev Recd Date: 2015-10-08

Publish Date: 2016-09-20

Key words:

Abstract: In layer-stacking conformal heavy-ion therapy based on passive beam delivery system,it is necessary to minimize the layer numbers and reduce irradiation time for layer-stacking conformal heavy-ion therapy.Gaussian shaped mini spread-out Bragg peaks (mini-SOBP) were generated by mini ridge filters (mini-RF) for monoenergetic heavy ion beams.It is effective to minimize the layer number by using mini-SOBPs with the bigger full width at the half maximum (FWHM),but in this way the distal dose fall-off distance of a spread-out Bragg peak (SOBP) will be enlarged,increasing the radiation damage to normal tissue or organ at risk behind the target volume.This issue could be solved by using mini-SOBPs based combinatorial irradiation method.In this study,Gaussian shaped mini-SOBPs with two different FWHMs were generated by two different mini-RFs for monoenergetic heavy ion beams.Based on radiobiological model calculations and dose optimizations,the mini-SOBPs based combinatorial irradiation method was confirmed to reduce the distal dose fall-off distances of SOBPs while minimizing the layer numbers for layer-stacking conformal heavy-ion therapy.

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Mini-SOBPs Based Combinatorial Irradiation Method in Heavy Ion Radiotherapy

doi: 10.11804/NuclPhysRev.33.03.345

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