Microbeam Application in Radiation Biology

GUO Na; DU Guanghua; LIU Wenjing; GUO Jinlong; WU Ruqun; CHEN Hao

doi:10.11804/NuclPhysRev.33.04.471

Volume 33 Issue 4

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Article Navigation > Nuclear Physics Review > 2016 > 33(4): 471-480

GUO Na, DU Guanghua, LIU Wenjing, GUO Jinlong, WU Ruqun, CHEN Hao. Microbeam Application in Radiation Biology[J]. Nuclear Physics Review, 2016, 33(4): 471-480. doi: 10.11804/NuclPhysRev.33.04.471

Citation:

GUO Na, DU Guanghua, LIU Wenjing, GUO Jinlong, WU Ruqun, CHEN Hao. Microbeam Application in Radiation Biology[J]. Nuclear Physics Review, 2016, 33(4): 471-480. doi: 10.11804/NuclPhysRev.33.04.471

Microbeam Application in Radiation Biology

doi: 10.11804/NuclPhysRev.33.04.471

1.
Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
2.
University of Chinese Academy of Sciences, Beijing 100049, China;
3.
LanZhou University, Lanzhou 730000, China

Funds: Hundred Talents Program of Chinese Academy of Sciences (Y150310BRO), National Natural Science Foundation of China(31200630, U1632271), Ministry of Science and Technology(2012YQ03014204)

Received Date: 2015-12-18
Rev Recd Date: 2016-01-20
Publish Date: 2016-12-20

Abstract

The microbeam facility can provide micrometer scale localized and predefined ionizing radiation in the life science study, and the microbeam techniques play a unique role in determining the target substances of ionizing radiation, as well as in the study of radiation sensitivity, mechanisms of radiation damage response and repair. This paper summarizes the technical developments of biological microbeam facilities and their applications in the studies of low-dose radiation effect, bystander effect and cellular signaling. This paper also introduces the recent developments at the heavy-ion microbeam facility in the Institute of Modern Physics (IMP), which can provide heavy ion microbeam irradiation with energy of 7~80 MeV/u and LET of 30~3000 keV/μm. The facility can perform radiobiological irradiation and online investigation in living cells and mice, including bystander effect study, sleeping system influence after irradiation to mice hypothalamus and the recruitment dynamics of XRCC1 protein.
- heavy ion,
- microbeam technique,
- radiation biology

References

[1]	ZIRKLE R E, BLOOM W. Science, 1953, 117:487.
[2]	GEARD C R, BRENNER D J, RANDERS-PEHRSON G, et al. Nucl Instr and Meth B, 1991, 54(1/3):411.
[3]	KAMIYA T, YOKOTA W, KOBAYASHI Y, et al. Nucl Instr and Meth B, 2001, 181:27.
[4]	LEGGE G J F. Nucl Instr and Meth B, 1997, 130(1/4):9.
[5]	FISCHER B E. Nucl Instr and Meth B, 1991, 54:401.
[6]	KOBAYASHI Y, FUNAYAMA T, HAMADA N, et al. J Radiat Res, 2009, 50:29.
[7]	GERARDI S. J Radiat Res, 2009, 50:13.
[8]	NAGASAWA H, LITTLE J B. Cancer Research, 1992, 52:6394.
[9]	PRISE K M, SCHETTINO G, VOJNOVIC B, et al. J Radiat Res, 2009, 50:1.
[10]	HU Zhiwen, WU Lijun, YU Zengliang. Plasma Science & Technology, 2005, 7(2):2789.
[11]	SONG Mingtao, SHENG Lina, WANG Zhiguang, et al. Chinese Physics C, 2008, 32:259. (in Chinese) (宋明涛, 盛丽娜, 王志光, 等. 中国物理C, 2008, 32:259.)
[12]	SHENG Lina, SONG Mingtao. Atomic Energy Science and Technology, 2008, 42:1135. (in Chinese) (盛丽娜, 宋明涛. 原子能科学技术, 2008, 42:1135.)
[13]	SHENG Lina, SONG Mingtao, LIU Jie, et al. Nuclear Physics Review, 2009, 26:215. (in Chinese) (盛丽娜, 宋明涛, 刘杰, 等. 原子核物理评论, 2009, 26:215.)
[14]	SHENG Lina, SONG Mingtao, ZHANG Xiaoqi, et al. Nucl Instr and Meth B, 2011, 269:2189.
[15]	DU Guanghua. Nuclear Physics Review, 2012, 29:371. (in Chinese) (杜广华. 原子核物理评论, 2012, 29:371.)
[16]	DU Guanghua, GUO Jinlong, WU Ruqun, et al. Nucl Instr and Meth B, 2015, 348:28.
[17]	DYMNIKOV A D, OVSYANNIKOVA L P, YAVOR S Y. Soviet Physics-Technical Physics (USA), 1963, 4:293.
[18]	FISCHER B E, SPOHR R. Nucl Instr and Meth, 1980, 168:241.
[19]	DEMORTIER G, MATHOT S, VANOYSTAEYEN B. Nucl Instr and Meth B, 1990, 49:46.
[20]	RYAN C G, JAMIESON D N. Nucl Instr and Meth B, 1993, 77:203.
[21]	KHODJA H, BERTHOUMIEUX E, DAUDIN L, et al. Nucl Instr and Meth B, 2001, 181:83.
[22]	MICHAEL B D, FOLKARD M, PRISE K M. Int J Radiat Biol, 1994, 65(4):503.
[23]	ROHRIG N, COLVETT R D, MARINO S A. Radiation Research, 1978, 74:485.
[24]	PENG Shixiang, GILCHRIST S, FOLKARD M, et al. Vacuum Science and Technology(China),2002,22:89. (in Chinese) (彭士香, GILCHRIST S, FOLKARD M, 等. 真空科学与技术, 2002, 22:89)
[25]	BIGELOW A, GARTY G, FUNAYAMA T, et al. J Radiat Res, 2009, 50:21.
[26]	VOSS K O, FOURNIER C, TAUCHER-SCHOLZ G. HeNew Journal of Physics, 2008, 10:075001.
[27]	DATZMANN G, DOLLINGER G, GOEDEN C, et al. Nucl Instr and Meth B, 2001, 181:20.
[28]	MORETTO P, MICHELET C, BALANA A, et al. Nucl Instr and Meth B, 2001, 181:104.
[29]	BIGELOW A W, ROSS G J, RANDERS-PEHRSON G, et al. Nucl Instr and Meth B, 2005, 231:202.
[30]	WANG Xufei, WANG Xiaohua, CHEN Lianyun, et al. Science China Press, 2004, 49:1677. (in Chinese) (王旭飞, 王晓华, 陈连运, 等. 科学通报, 2004, 49:1677.)
[31]	LI Jiaqing, WANG Xufei, ZHANG Jiexiong, et al. Atomic Energy Science and Technology, 2013, 47:1916. (in Chinese) (李嘉庆, 王旭飞, 张杰雄, 等. 原子能科学技术, 2013, 47:1916.)
[32]	FENG Y, HUA G, LIU S. Journal of Astronautics, 2007, 28:1071. (in Chinese) (冯彦君, 华更新, 刘淑芬. 宇宙学报, 2007, 28:1071.)
[33]	WANG T, SHEN Y, WANG S, et al. Journal of National University of Defense Technology, 1999, 21:36. (in Chinese) (王同权, 沈永平, 王尚武, 等. 1999, 21:36.)
[34]	NAGASAWA H, LITTLE J B. Cancer Research, 1992, 52:6394.
[35]	DESHPANDE A, GOODWIN EH, BAILEY SM, et al. Radiat Res, 1996, 145(3):260.
[36]	ZHOU H, RANDERS-PEHRSON G, WALDREN C A, et al. Proc Natl Acad Sci, 2000, 97:2099.
[37]	WU L, RANDERS-PEHRSON G, XU A, et al. Proc Natl Acad Sci USA, 1999, 96:4959.
[38]	PRISE K M, BELYAKOV O V, FOLKARD M, et al. International Journal of Radiation Biology, 1998, 74(6):793.
[39]	BELYAKOV O V, MALCOLMSON A M, FOLKARD M, et al. British Journal of Cancer, 2001, 84(5):674.
[40]	TARTIER L, GILCHRIST S, BURDAK-ROTHKAMM S, et al. Cancer Res, 2007, 67:5872.
[41]	EUKEL W W, HUBER W. Food Technology, 1960, 14:198.
[42]	COLLINS V P. Journal of Nuclear Medicine, 1960, 1:110.
[43]	MCCORMIC W G, STEFF S. Obstetrics and Gynecology, 1970, 36:688.
[44]	WARREN S. Journal of Forensic Sciences, 1980, 25:721.
[45]	DAHL O, HORN A, MORILD I, et al. Cancer, 1990, 66:2286.
[46]	PRISE K M, FOLKARD M, MICHAEL B D. Radiation Protection Dosimetry, 2003, 104(4):347.
[47]	BRENNER D J, DOLL R, GOODHEAD D T, et al. Proc Natl Acad Sci, 2003, 100:13761.
[48]	ZIRKLE R E. New York:Academic Press, 1957, 103.
[49]	BLOOM W. Reviews of Modern Physics, 1959, 31:66.
[50]	SETLOW R B. Mutation Research, 1999, 430:169.
[51]	SCHIMMERLING W. Radiation and Environmental Biophysics, 1995, 34:133.
[52]	SCHETTINO G, FOLKARD M, PRISE K M, et al. Radiation research, 2001, 156(5 Pt 1):526.
[53]	GERARDI S, GALEAZZI G, CHERUBINI R. Radiation Research, 2005, 164(4 Pt 2):586.
[54]	MAEDA M, USAMI N, KOBAYASHI K. Journal of radiation research, 2008, 49(2):171.
[55]	UGENSKIENE R, PRISE K, FOLKARD M, et al. International Journal of Radiation Biology, 2009, 85(10):872.
[56]	CHOI V W, YUM E H, KONISHI T, et al. Journal of Radiation Research, 2012, 53(3):475.
[57]	TOMITA M, MAEDA M. Journal of Radiation Research, 2015, 56(2):205.
[58]	DU G, FISCHER B E, VOSS K O. Nucl Instr and Meth B, 2011, 269:2312.
[59]	MERK B, VOSS K O, MULLER I, et al. Nucl Instr and Meth B, 2013, 306:81.
[60]	HABLE V, GREUBEL C, BERGMAIER A, et al. Nucl Instr and Meth B, 2009, 267(12-13):2090.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Microbeam Application in Radiation Biology

1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

2. University of Chinese Academy of Sciences, Beijing 100049, China;

3. LanZhou University, Lanzhou 730000, China

Funds: Hundred Talents Program of Chinese Academy of Sciences (Y150310BRO), National Natural Science Foundation of China(31200630, U1632271), Ministry of Science and Technology(2012YQ03014204)

Received Date: 2015-12-18

Rev Recd Date: 2016-01-20

Publish Date: 2016-12-20

Key words:

Abstract: The microbeam facility can provide micrometer scale localized and predefined ionizing radiation in the life science study, and the microbeam techniques play a unique role in determining the target substances of ionizing radiation, as well as in the study of radiation sensitivity, mechanisms of radiation damage response and repair. This paper summarizes the technical developments of biological microbeam facilities and their applications in the studies of low-dose radiation effect, bystander effect and cellular signaling. This paper also introduces the recent developments at the heavy-ion microbeam facility in the Institute of Modern Physics (IMP), which can provide heavy ion microbeam irradiation with energy of 7~80 MeV/u and LET of 30~3000 keV/μm. The facility can perform radiobiological irradiation and online investigation in living cells and mice, including bystander effect study, sleeping system influence after irradiation to mice hypothalamus and the recruitment dynamics of XRCC1 protein.

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Reference (60)

[1]	ZIRKLE R E, BLOOM W. Science, 1953, 117:487.
[2]	GEARD C R, BRENNER D J, RANDERS-PEHRSON G, et al. Nucl Instr and Meth B, 1991, 54(1/3):411.
[3]	KAMIYA T, YOKOTA W, KOBAYASHI Y, et al. Nucl Instr and Meth B, 2001, 181:27.
[4]	LEGGE G J F. Nucl Instr and Meth B, 1997, 130(1/4):9.
[5]	FISCHER B E. Nucl Instr and Meth B, 1991, 54:401.
[6]	KOBAYASHI Y, FUNAYAMA T, HAMADA N, et al. J Radiat Res, 2009, 50:29.
[7]	GERARDI S. J Radiat Res, 2009, 50:13.
[8]	NAGASAWA H, LITTLE J B. Cancer Research, 1992, 52:6394.
[9]	PRISE K M, SCHETTINO G, VOJNOVIC B, et al. J Radiat Res, 2009, 50:1.
[10]	HU Zhiwen, WU Lijun, YU Zengliang. Plasma Science & Technology, 2005, 7(2):2789.
[11]	SONG Mingtao, SHENG Lina, WANG Zhiguang, et al. Chinese Physics C, 2008, 32:259. (in Chinese) (宋明涛, 盛丽娜, 王志光, 等. 中国物理C, 2008, 32:259.)
[12]	SHENG Lina, SONG Mingtao. Atomic Energy Science and Technology, 2008, 42:1135. (in Chinese) (盛丽娜, 宋明涛. 原子能科学技术, 2008, 42:1135.)
[13]	SHENG Lina, SONG Mingtao, LIU Jie, et al. Nuclear Physics Review, 2009, 26:215. (in Chinese) (盛丽娜, 宋明涛, 刘杰, 等. 原子核物理评论, 2009, 26:215.)
[14]	SHENG Lina, SONG Mingtao, ZHANG Xiaoqi, et al. Nucl Instr and Meth B, 2011, 269:2189.
[15]	DU Guanghua. Nuclear Physics Review, 2012, 29:371. (in Chinese) (杜广华. 原子核物理评论, 2012, 29:371.)
[16]	DU Guanghua, GUO Jinlong, WU Ruqun, et al. Nucl Instr and Meth B, 2015, 348:28.
[17]	DYMNIKOV A D, OVSYANNIKOVA L P, YAVOR S Y. Soviet Physics-Technical Physics (USA), 1963, 4:293.
[18]	FISCHER B E, SPOHR R. Nucl Instr and Meth, 1980, 168:241.
[19]	DEMORTIER G, MATHOT S, VANOYSTAEYEN B. Nucl Instr and Meth B, 1990, 49:46.
[20]	RYAN C G, JAMIESON D N. Nucl Instr and Meth B, 1993, 77:203.
[21]	KHODJA H, BERTHOUMIEUX E, DAUDIN L, et al. Nucl Instr and Meth B, 2001, 181:83.
[22]	MICHAEL B D, FOLKARD M, PRISE K M. Int J Radiat Biol, 1994, 65(4):503.
[23]	ROHRIG N, COLVETT R D, MARINO S A. Radiation Research, 1978, 74:485.
[24]	PENG Shixiang, GILCHRIST S, FOLKARD M, et al. Vacuum Science and Technology(China),2002,22:89. (in Chinese) (彭士香, GILCHRIST S, FOLKARD M, 等. 真空科学与技术, 2002, 22:89)
[25]	BIGELOW A, GARTY G, FUNAYAMA T, et al. J Radiat Res, 2009, 50:21.
[26]	VOSS K O, FOURNIER C, TAUCHER-SCHOLZ G. HeNew Journal of Physics, 2008, 10:075001.
[27]	DATZMANN G, DOLLINGER G, GOEDEN C, et al. Nucl Instr and Meth B, 2001, 181:20.
[28]	MORETTO P, MICHELET C, BALANA A, et al. Nucl Instr and Meth B, 2001, 181:104.
[29]	BIGELOW A W, ROSS G J, RANDERS-PEHRSON G, et al. Nucl Instr and Meth B, 2005, 231:202.
[30]	WANG Xufei, WANG Xiaohua, CHEN Lianyun, et al. Science China Press, 2004, 49:1677. (in Chinese) (王旭飞, 王晓华, 陈连运, 等. 科学通报, 2004, 49:1677.)
[31]	LI Jiaqing, WANG Xufei, ZHANG Jiexiong, et al. Atomic Energy Science and Technology, 2013, 47:1916. (in Chinese) (李嘉庆, 王旭飞, 张杰雄, 等. 原子能科学技术, 2013, 47:1916.)
[32]	FENG Y, HUA G, LIU S. Journal of Astronautics, 2007, 28:1071. (in Chinese) (冯彦君, 华更新, 刘淑芬. 宇宙学报, 2007, 28:1071.)
[33]	WANG T, SHEN Y, WANG S, et al. Journal of National University of Defense Technology, 1999, 21:36. (in Chinese) (王同权, 沈永平, 王尚武, 等. 1999, 21:36.)
[34]	NAGASAWA H, LITTLE J B. Cancer Research, 1992, 52:6394.
[35]	DESHPANDE A, GOODWIN EH, BAILEY SM, et al. Radiat Res, 1996, 145(3):260.
[36]	ZHOU H, RANDERS-PEHRSON G, WALDREN C A, et al. Proc Natl Acad Sci, 2000, 97:2099.
[37]	WU L, RANDERS-PEHRSON G, XU A, et al. Proc Natl Acad Sci USA, 1999, 96:4959.
[38]	PRISE K M, BELYAKOV O V, FOLKARD M, et al. International Journal of Radiation Biology, 1998, 74(6):793.
[39]	BELYAKOV O V, MALCOLMSON A M, FOLKARD M, et al. British Journal of Cancer, 2001, 84(5):674.
[40]	TARTIER L, GILCHRIST S, BURDAK-ROTHKAMM S, et al. Cancer Res, 2007, 67:5872.
[41]	EUKEL W W, HUBER W. Food Technology, 1960, 14:198.
[42]	COLLINS V P. Journal of Nuclear Medicine, 1960, 1:110.
[43]	MCCORMIC W G, STEFF S. Obstetrics and Gynecology, 1970, 36:688.
[44]	WARREN S. Journal of Forensic Sciences, 1980, 25:721.
[45]	DAHL O, HORN A, MORILD I, et al. Cancer, 1990, 66:2286.
[46]	PRISE K M, FOLKARD M, MICHAEL B D. Radiation Protection Dosimetry, 2003, 104(4):347.
[47]	BRENNER D J, DOLL R, GOODHEAD D T, et al. Proc Natl Acad Sci, 2003, 100:13761.
[48]	ZIRKLE R E. New York:Academic Press, 1957, 103.
[49]	BLOOM W. Reviews of Modern Physics, 1959, 31:66.
[50]	SETLOW R B. Mutation Research, 1999, 430:169.
[51]	SCHIMMERLING W. Radiation and Environmental Biophysics, 1995, 34:133.
[52]	SCHETTINO G, FOLKARD M, PRISE K M, et al. Radiation research, 2001, 156(5 Pt 1):526.
[53]	GERARDI S, GALEAZZI G, CHERUBINI R. Radiation Research, 2005, 164(4 Pt 2):586.
[54]	MAEDA M, USAMI N, KOBAYASHI K. Journal of radiation research, 2008, 49(2):171.
[55]	UGENSKIENE R, PRISE K, FOLKARD M, et al. International Journal of Radiation Biology, 2009, 85(10):872.
[56]	CHOI V W, YUM E H, KONISHI T, et al. Journal of Radiation Research, 2012, 53(3):475.
[57]	TOMITA M, MAEDA M. Journal of Radiation Research, 2015, 56(2):205.
[58]	DU G, FISCHER B E, VOSS K O. Nucl Instr and Meth B, 2011, 269:2312.
[59]	MERK B, VOSS K O, MULLER I, et al. Nucl Instr and Meth B, 2013, 306:81.
[60]	HABLE V, GREUBEL C, BERGMAIER A, et al. Nucl Instr and Meth B, 2009, 267(12-13):2090.

Microbeam Application in Radiation Biology

doi: 10.11804/NuclPhysRev.33.04.471

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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