Dependence of Relative Biological Effectiveness on Dose in Hypofractionated Carbon Ion Beam Radiotherapy

DAI Tianyuan; LI Qiang; CHEN Weiqiang; LIU Xinguo; DAI Zhongying

doi:10.11804/NuclPhysRev.34.04.784

Short treatment course due to the suitability of hypofractionated regimen for carbon ion beam is one of the advantages of carbon ion radiotherapy. To study the dependence of relative biological effectiveness (RBE) on dose, the relationship between RBE and dose was deduced through the linear-quadratic (LQ) model. Based on the relationship, the change of RBE of tumor cells and normal tissue cells with different radiosensitivities with dose was studied. The results showed that the RBE value of tumor cells was always greater than that of normal tissue cells in the dose range of 0~20 Gy, regardless of the radiosensitivity of tumor and normal tissue cells. In addition, based on theoretical deduction and analysis of the relevant experimental data, the existence of RBE increase with increasing dose was verified. These results are of great significance for conducting hypofractionated radiotherapy with carbon ion beam.

Dependence of Relative Biological Effectiveness on Dose in Hypofractionated Carbon Ion Beam Radiotherapy

1. Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;

2. Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;

3. Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou 730000, China;

4. University of Chinese Academy of Sciences, Beijing 100049, China

Funds: Key Project of National Natural Science Foundation of China(U1232207);National Key Technology Support Program of Ministry of Science and Technology of China(2015BAI01B11);National Natural Science Foundation of China(11205217, 11475231, 11075191);National Key Research and Development Program of China(2016YFC0904600)

Received Date: 2017-01-12

Rev Recd Date: 2017-04-01

Publish Date: 2017-12-20

Key words:

Abstract: Short treatment course due to the suitability of hypofractionated regimen for carbon ion beam is one of the advantages of carbon ion radiotherapy. To study the dependence of relative biological effectiveness (RBE) on dose, the relationship between RBE and dose was deduced through the linear-quadratic (LQ) model. Based on the relationship, the change of RBE of tumor cells and normal tissue cells with different radiosensitivities with dose was studied. The results showed that the RBE value of tumor cells was always greater than that of normal tissue cells in the dose range of 0~20 Gy, regardless of the radiosensitivity of tumor and normal tissue cells. In addition, based on theoretical deduction and analysis of the relevant experimental data, the existence of RBE increase with increasing dose was verified. These results are of great significance for conducting hypofractionated radiotherapy with carbon ion beam.

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Reference (28)

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Dependence of Relative Biological Effectiveness on Dose in Hypofractionated Carbon Ion Beam Radiotherapy

doi: 10.11804/NuclPhysRev.34.04.784

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