Monte Carlo Study on the Performance of 200 MeV Proton Therapy Energy Degraders Made of Different Materials

LIU Hongdong; YANG Lu; PEI Xi; CHEN Zhi; XU Xiey

doi:10.11804/NuclPhysRev.35.01.078

Energy selection system (ESS) is an important component for medical proton cyclotron system. It has been widely used to modulate the proton energy in accordance with treatment requirements. ESS consists of the energy degrader which was mostly made of graphite. Recent years, to improve the transmission efficiency of the proton beams, beryllium and boron carbide have been proposed to substitute the graphite. In this work, the Monte Carlo code, TOPAS, was used to simulate the transport process of 200 MeV proton beams traversing the multi-wedge energy degrader made of graphite, beryllium and boron carbide, respectively. Energy fluxes of the protons and secondary neutrons after degrader, as well as the energy dispersion of the degraded proton beams, were calculated. It is found that the energy dissipation effect is nearly identical for all three kinds of degrader material, but using the beryllium or even boron carbide can improve the proton transmission efficiency. However, more secondary neutrons would be produced when proton beams interact with the beryllium and boron carbide, suggesting the need of additional consideration for radiation shielding to devices.

Monte Carlo Study on the Performance of 200 MeV Proton Therapy Energy Degraders Made of Different Materials

School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, 230027, China

Funds: National Natural Science Foundation of China (11575180); National Key R&D Program of China (2017YFC0107500)

Received Date: 2017-05-17

Rev Recd Date: 2017-06-13

Publish Date: 2018-03-20

Key words:

Abstract: Energy selection system (ESS) is an important component for medical proton cyclotron system. It has been widely used to modulate the proton energy in accordance with treatment requirements. ESS consists of the energy degrader which was mostly made of graphite. Recent years, to improve the transmission efficiency of the proton beams, beryllium and boron carbide have been proposed to substitute the graphite. In this work, the Monte Carlo code, TOPAS, was used to simulate the transport process of 200 MeV proton beams traversing the multi-wedge energy degrader made of graphite, beryllium and boron carbide, respectively. Energy fluxes of the protons and secondary neutrons after degrader, as well as the energy dispersion of the degraded proton beams, were calculated. It is found that the energy dissipation effect is nearly identical for all three kinds of degrader material, but using the beryllium or even boron carbide can improve the proton transmission efficiency. However, more secondary neutrons would be produced when proton beams interact with the beryllium and boron carbide, suggesting the need of additional consideration for radiation shielding to devices.

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Reference (28)

[1]	PAGANETTI H, Proton Therapy Physics[M]. Boca Raton:CRC Press, 2012:20.
[2]	LIU SHIYAO, Proton and Heavy Ion Therapy and the Devices[M]. Beijing:Science Press, 2012:17. (in chinese) (刘世耀. 质子和重离子治疗及其装置[M]. 北京:科学出版社, 2012:17.)
[3]	LUNDKVIST J, EKMAN M, ERICSSON S R, et al. Acta oncologica, 2005, 44(8):850.
[4]	JERMANN M. International Journal of Particle Therapy, 2015, 2(1):50.
[5]	ROSSI JR C J. Intensity-Modulated Proton Beam Therapy of Prostate Cancer-History, Results, and Future Directions[M]//WONG J, SCHUTHEISS T, RADANY E. Advances in Radiation Oncology, Berlin:Springer International Publishing, 2017:109.
[6]	JONGEN Y. Review on Cyclotrons for Cancer Therapy[C]. Proceedings of Cyclotrons 2010:58.
[7]	WIESZCZYCKA W, SCHARF W H. Proton radiotherapy accelerators[M]. Singapore:World Scientific, 2001:17.
[8]	KOSTROMIN S, GURSKY S, KARAMYSHEVA G, et al. Development of the IBA-JINR cyclotron C235-V3 for Dimitrovgrad Hospital Center of the Proton Therapy[C]. Proc of RUPAC, 2012:221.
[9]	LEE S K, LEE H R, KIM K R, et al. Characteristic Experimentations of Degrader and Scatterer at MC-50 Cyclotron[C]. Particle Accelerator Conference, PAC 2005, Proceedings of the IEEE, 2005:1356.
[10]	SCHILLO M, GEISLER A, HOBL A, et al. Compact Superconducting 250 MeV Proton Cyclotron for the PSI Proscan Proton Therapy Project[C]. AIP Conference Proceedings, 2001, 600(1):37.
[11]	PEDRONI E, BACHER R, BLATTMANN H, et al. Medical Physics, 1995, 22(1):37.
[12]	REIST H, DOLLING R, GRAF M, et al. A Fast Degrader to set the Energies for the Application of the Depth Dose in Proton Therapy[C]. Scientific and Technical Report 2001, 2002:20.
[13]	CASCIO E W, SARKAR S. A Continuously Variable Water Beam Degrader for the Radiation Test Beamline at the Francis H. Burr Proton Therapy Center[C]. Radiation Effects Data Workshop, IEEE, 2007:30.
[14]	OWEN H, HOLDER D, ALONSO J, et al. International Journal of Modern Physics A, 2014, 29(14):1441002.
[15]	STICHELBAUT F, JONGEN Y. Properties of an energy degrader for light ions[C]. Progress in Nuclear Science and Technology, 2014, 4:272.
[16]	BRENNSETER J A. The Influence of the Energy Degrader Material for a Therapeutical Proton Beam[D]. Norway:Norwegian University of Science and Technology, 2015:5.
[17]	ANFEROV V. Nucl Instr Meth A, 2003, 496(1):222.
[18]	VAN GOETHEM M J, VAN D M R, REIST H W, et al. Physics in Medicine and Biology, 2009, 54(54):5831.
[19]	GERBERSHAGEN A, BAUMGARTEN C, KISELEV D, et al. Physics in Medicine and Biology, 2016, 61(14):N337.
[20]	PAGANETTI H, JIANG H, LEE S Y, et al. Medical Physics, 2004, 31(7):2107.
[21]	PERL J, SHIN J, SCHUMANN J, et al. Medical Physics, 2012, 39(11):6818.
[22]	TESTA M, SCHUMANN J, LU H M, et al. Medical Physics, 2013, 40(12):121719.
[23]	PERL J. User Guide for TOPAS Version 3.0(rev. 201605-22b). 2016:72.
[24]	ASO T, KIMURA A, TANAKA S, et al. IEEE transactions on Nuclear Science, 2005, 52(4):896.
[25]	Geant4 Collaboration. geant4 User's Guide for Application Developers[EB/OL].[2014-12-5].
[26]	JARLSKOG C Z, PAGANETTI H. IEEE Transactions on Nuclear Science, 2008, 55(3):1018.
[27]	PAGANETTI H. Physics in Medicine and Biology, 2012, 57(11):R99.
[28]	URBAN T, KLUSON J. Radioprotection, 2012, 47(04):583.

Monte Carlo Study on the Performance of 200 MeV Proton Therapy Energy Degraders Made of Different Materials

doi: 10.11804/NuclPhysRev.35.01.078

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