Applications of Zebra sh Embryo in Ionizing Radiation Biology
- Received Date: 2015-09-09
- Accepted Date: 2016-03-20
- Rev Recd Date: 2016-05-06
- Publish Date: 2016-03-20
Abstract: Zebrafish embryo is a classic animal model to study developmental and molecular biology. The relatedworks using zebrafish embryo arise from less than 100 papers per year in 90 s to more than 1 000 papers per year at the beginning of 21st century. The research scope and application value of zebrafish embryo in biology studies are gradually extending, along with the exponential increase of related papers. Here, the applications of zebrafish embryo in the field of radiation biology are reviewed, including radiation-induced toxicity, signal transduction in response to radiation-induced DNA damage, and the assessment of radio-protection and radiosensitizers, respectively. The progress in radiation biology employing zebrafish embryo in Institute of Modern Physics has also been reported, includinga novel mitochondrial reactive oxygen species inducer, which can be triggered by exogenous physical signal and exert chemical stimulation. This inducer shows no obvious embryo toxicity to zebrafish under 10 μL/mL. It can induce DNA double strand breaks if activated by certain wavelength of lights. Itisa potential radiosensitizerin theory.
|Citation:||WANG Yupei. Applications of Zebra sh Embryo in Ionizing Radiation Biology[J]. Nuclear Physics Review, 2016, 33(1): 94-104. doi: 10.11804/NuclPhysRev.33.01.094|